CrossRef 39. Humphreys DT, Carver JA, Easterbrook-Smith SB, Wilson MR: Clusterin has chaperone-like activity similar to that of small heat shock proteins. J Biol Chem 1999, 274:6875–81.PubMedCrossRef 40. Watari H, Kanuma T, Ohta Y, Hassan MK, Mitamura T, Hosaka M, et al.: Clusterin expression inversely correlates with chemosensitivity and predicts poor survival in patients with locally advanced cervical cancer treated with cisplatin-based neoadjuvant chemotherapy and radical hysterectomy. Pathol Oncol
Res 2010, 16:345–52.PubMedCrossRef learn more 41. Hoeller C, Pratscher B, Thallinger C, Winter D, Fink D, Kovacic B, et al.: Clusterin regulates drug-resistance in melanoma cells. J Invest Dermatol 2005, 124:1300–7.PubMedCrossRef 42. Albert JM, Gonzalez A, Massion PP, Chen H, Olson SJ, Shyr Y, Diaz R, Lambright ES, Sandler A, Carbone DP, Putnam JB Jr, Johnson DH, et al.: Cytoplasmic clusterin expression is associated with longer survival in patients with resected non small cell lung cancer. Cancer Epidemiol Biomarkers Prev 2007, 16:1845–51.PubMedCrossRef 43. Wu AJ, Park II, Zhaung L, Lee C: Response to a lethal dose of heat shock by a transient up-regulation of clusterin expression followed by down-regulation and apoptosis in prostate and bladder cancer cells. Prostate 2002, 53:277–85.PubMedCrossRef
44. Miyake H, Hara I, Gleave ME: Antisense oligodeoxynucleotide therapy targeting clusterin gene for prostate cancer : Vancouver experience from discovery to clinic. Int J Urol 2005, 12:785–94.PubMedCrossRef selleck compound 45. Sowery RD, Hadaschik BA, So AI, Zoubeidi A, Fazli L, Hurtado-Coll A, et al.: Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy. B J U Int 2008, 102:389–97.CrossRef 46. Gleave M, Miyake H: Use of antisense oligonucleotides targeting Aldehyde dehydrogenase the cytoprotective gene, clusterin, to enhance androgen- and chemosensitivity in prostate cancer. World J Urol 2005, 23:38–46.PubMedCrossRef 47. Choueiri TK, Mekhail T, Hutson TE, Ganapathi R, Kelly GE, Bukowski RM: Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with
solid cancer. Ann Oncol 2006, 17:860–5.PubMedCrossRef 48. Cummings J, Ward TH, LaCasse E, Lefebvre C, St-Jean M, Durkin J, et al.: Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. Br J Cancer 2005, 92:532–8.PubMed 49. Chi KN, Hotte SJ, Yu EY, Tu D, Eigl BJ, Tannock I, Saad F, North S, Powers J, Gleave ME, Eisenhauer EA: check details Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer. J Clin Onco 2010, 28:4247–54.CrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions MH, HW and ST designed the study.