\n\nConclusion: Taenia multiceps, is a relatively important zoonotic infection in Iranian sheep with the prevalence rate of 2.5%. Hook length analysis
revealed statistically significant difference among individual isolates. Associations between the rostellar hook length and variability in the mitochondrial 12S rRNA was documented.”
“Aims: ATP-binding cassette transporter A1 (ABCA1) mediates the efflux of cholesterol and phospholipids to lipid-poor apolipoproteins, which then form nascent HDL, a key step in the mechanism of reverse cholesterol transport (RCT). While a series of microRNAs (miRNAs) have been identified as potent post-transcriptional regulators of lipid metabolism, their effects on ABCA1 function and associated mechanisms remain unclear. Methods and Results: ABCA1 was identified as a potential TPX-0005 datasheet target of miR-144-3p, based on the results of selleck chemical bioinformatic analysis and
the luciferase reporter assay, and downregulated after transfection of cells with miR-144-3p mimics, as observed with real-time PCR and western blot. Moreover, miR-144-3p mimics (agomir) enhanced the expression of inflammatory factors, including IL-1 beta, IL-6 and TNF-alpha, in vivo and in vitro, inhibited cholesterol efflux in THP-1 macrophage-derived foam cells, decreased HDL-C circulation and impaired RCT in vivo, resulting in accelerated pathological progression of atherosclerosis in apoE(-/-) mice. Clinical studies additionally revealed a positive correlation of circulating miR-144-3p with serum CK, CK-MB, LDH and AST in subjects with AMI. Conclusions: Our findings clearly indicate that miR-144-3p is essential for the regulation of cholesterol homeostasis and HSP990 in vitro inflammatory reactions, supporting its utility as a potential therapeutic target of atherosclerosis and a promising diagnostic biomarker of AMI.”
“The ghost crab Ocypode quadrata plays an important role in energy transfer between trophic levels, and
has been widely used in evaluations of impacted environments. In order to provide data on the biology of this potential bioindicator species, the population structure and vertical distribution of individuals were studied on two beaches in southeastern Brazil. Each beach was divided into quadrants of 1000 m(2) with boundaries of upper, middle and lower levels in relation to the waterline. Collected monthly by active searching through one year, the specimens of O. quadrata were sexed, measured for carapace width, and returned to the beach. Of the total of 1904 specimens collected, the largest proportion (46.2%) were males, followed by 31.4% juveniles. The vertical distribution of the ghost crabs differed among age groups: males mostly occupied the middle and upper levels; adult females, ovigerous or not, were more abundant in the lower level; and juveniles were evenly distributed in all levels, with a slight tendency toward the middle. The sex ratio favored males in a few months of the year and in the larger size classes.