Methods: The study group consisted of 496 patients in whom a DDD pacing system was implanted between October 1984 and March 2002 and who were followed up until July 2010. The follow-up period was 152.1 +/- 35.5 months. The patients’ mean age at the time of implantation was 59.5 +/- 12.5 years, and 53.5% were male; 58% had sick sinus syndrome (SSS), 26% had atrioventricular block (AVB), 15% had both of these indications simultaneously, and 1% had other indications. The incidence of lead malfunction, progression to chronic atrial fibrillation

(AF), and the rate of infective complications was analysed. Results: During the follow-up, 369 patients remained in DDD mode stimulation. DDD mode survival mTOR inhibitor rate at one, five, ten and 15 years was, respectively, 96%, 86%, 77% and 72%. The most common reason for reprogramming out of DDD mode was the development of permanent AF in 65 (13.1%) patients. The

occurrence of chronic AF RG-7388 inhibitor was associated with a prior history of paroxysmal AF (p = 0.0001), SSS (p = 0.0215), and older age at time of implantation (p = 0.0068) compared to patients who remained in sinus rhythm. Lead malfunction caused loss of DDD mode pacing in 56 (11.3%) patients. Atrial leads were damaged in 37 patients, ventricular in 12 patients, and both leads in seven patients. The subclavian vein puncture was correlated with the mechanical damage of the atrial lead (p = 0.02935) compared to cephalic vein access. At the moment of complication, the patients with a dysfunctional lead were significantly younger than those who progressed to chronic AF (p = 0.0019). Infective complications which caused temporary loss of DDD pacing were observed in six patients: five had pocket infection and one had lead-dependent infective endocarditis. Conclusions: 1. Effective DDD pacing from the originally implanted system was noted selleck compound in a high percentage (72%) of patients in long-term observation (15 years). 2. Progression to permanent AF is the most common reason for loss of DDD pacing; a history of paroxysmal AF and old age are the risk factors. 3. Subclavian vein puncture is

associated with a higher rate of atrial lead damage.”
“Background: This study aims to investigate possible factors other than lymph node invasion and cell type which may affect survival in patients with lung carcinoids over long-term follow-up. Methods: This retrospective study included 82 patients (36 males, 46 females; mean age 43.8 years; range 16 to 19 years) operated with a diagnosis of bronchial carcinoid between February 1993 and November 2012. Factors that may affect survival were identified as age, sex, location of surgery, T status, N status, complete resection, resection width, cell type, and stage. Morbidities and mortalities were recorded according to these factors. Results: Mean duration of follow-up was 84 months. Ten-year survival rate was 98.5%. Of patients, 49 were T-1, 29 were T-2, and four were T-3.

Ferret embryos at the morula (MR), compact morula (CM), and early blastocyst (EB) stages were vitrified using an Eppendorf microloader pipette tip as the chamber vessel. The rate of in vitro development was significantly (P < 0.05) Kinase Inhibitor Library solubility dmso higher among embryos vitrified at the CM (93.6%) and EB (100%) stages relative to those vitrified at the MR stages (58.7%). No significant developmental differences

were observed when comparing CM and EB vitrified embryos with nonvitrified control CM (100%) and EB (100%) embryos. In addition, few differences in the ultrastructure of intracellular lipid droplets or in microfilament structure were observed between control embryos and embryos vitrified at any developmental stage. Vitrified-thawed CM/EB embryos cultured for 2 or 16 h before ET resulted in live birth rates of 71.3% and 77.4%, respectively. These rates were not significantly different from the control live birth rate (79.2%). However, culture for 32 h (25%) or 48 h (7.8%)

after vitrification significantly reduced the rate of live births. These data indicate that the pipette chamber vitrification technique significantly improves the live birth rate of transferred ferret embryos relative to current state-of-the-art methods.”
“Group-2 late embryogenesis abundant (LEA) proteins, also known as dehydrins, are claimed to stabilize macromolecules against damage caused by freezing, dehydration, ionic or osmotic stresses. However, their precise function remains unknown. Selleckchem PP2 Here, we investigated the effect of wheat dehydrin (DHN-5) protein on the activity and thermostability of two distinct enzymes, Selleckchem GSK3326595 beta-glucosidase (bglG) and glucose oxidase/peroxidase (GOD/POD) in vitro. The purified DHN-5

protein had the capacity to preserve and stabilize the activity of bglG subjected to heat treatment. In addition, DHN-5 stabilized oxidizing enzymes, as it improved reliability in measuring glucose concentrations with a glucose oxidase/peroxidase (GOD/POD) kit while the temperature increased from 37 to 70 degrees C. All together the data presented provide evidence that DHN-5 is a dehydrin able to preserve enzyme activities in vitro from adverse effects induced by heating.”
“Two new indolizidine alkaloids, (+/-)-3-oxoisoelaeocarpine (1) and (+/-)-elaeocarpine N-oxide (2), along with three known alkaloids, (+/-)-isoelaeocarpine (3), (+/-)-elaeocarpine (4), and (-)-isoelaeocarpiline (5), were isolated from an EtOH extract of the branches and leaves of Elaeocarpus sphaericus. The structures of these compounds were determined by spectroscopic and chemical methods. Furthermore, enantiomers of compounds 1 and 3 were separated on a chiral CD-Ph column, and their absolute configurations were determined by TD-DFT (time-dependent density-functional theory) quantum-chemical calculations of their electronic circular dichroism (ECD) spectra.

By using air pressure data and PM(10) concentration measurements, the quantitative relationship between pressure variability and PK variation in different

sections of the anticyclone was established. A linear relationship was assumed between PM(10) variation Adriamycin inhibitor per unit area in the mixing layer and pressure variation within a time interval, and different sections of the anticyclone were associated with different linear regression equations. A parameter called PM(10) variation rate was then put forward, which could be easily applied for regional air pollution control and management. (C) 2011 Elsevier Ltd. All rights reserved.”
“Introduction: This study compared survival after initial treatment with esophagectomy as primary therapy to induction therapy followed by

esophagectomy for patients with clinical T2N0 (cT2N0) esophageal cancer in the National Cancer Database (NCDB). Methods: Predictors of therapy selection for patients with cT2N0 esophageal cancer in the NCDB from 1998 to 2011 were identified with multivariable logistic regression. Survival was evaluated using Kaplan-Meier and Cox proportional Microtubule Associat inhibitor hazards methods. Results: Surgery was used in 42.9% (2057

of 4799) of cT2N0 patients. Of 1599 esophagectomy patients for whom treatment timing was recorded, induction therapy was used in 44.1% (688). Pretreatment staging was proven accurate in only 26.7% of patients (210 of 786) who underwent initial surgery without induction treatment and had complete pathologic data MDV3100 nmr available: 41.6% (n = 327) were upstaged and 31.7% (n = 249) were downstaged. Adjuvant therapy (chemotherapy or radiation therapy) was given to 50.2% of patients treated initially with surgery who were found after resection to have nodal disease. There was no significant difference in long-term survival between strategies of primary surgery and induction therapy followed by surgery (median 41.1 versus 41.9 months, p = 0.51). In multivariable analysis, induction therapy was not independently associated with risk of death (hazard ratio [HR], 1.16, p = 0.32). Conclusions: Current clinical staging for early-stage esophageal cancer is highly inaccurate, with only a quarter of surgically resected cT2N0 patients found to have had accurate pretreatment staging. Induction therapy for patients with cT2N0 esophageal cancer in the NCDB is not associated with improved survival.

044), ciliary motility (p<0.001) and abnormalities in nasal secretions. A univariate logistic model, in which the odd ratio (OR) indicates the probability of success in the 9 mg sodium hyaluronate group compared to the control group, showed that the highest OR was observed for presence of nasal dyspnoea (OR=21.36; 95% CI: 1.07 to 426.56), normal mucosa at endoscopy (OR: 9.62; 95% CI: 1.82 to 50.89), ciliary motility (OR: 7.27; 95% CI: 1.68 to 31.42) and presence of bio film (OR: 4.41; 95% CI: 1.26 to 15.40). Treatment with 9 mg sodium hyaluronate plus saline was well tolerated. A 3-month intermittent treatment with 9 mg sodium hyaluronate plus saline solution nasal

washes following FESS for rhino-sinusal remodelling was associated with significant Rigosertib Cell Cycle inhibitor improvements in nasal dyspnoea, appearance of nasal mucosa at endoscopy and ciliary motility compared to saline alone.”
“Viral miocarditis is a common cardiovascular disease, which has greatly threatened human health. However, up to now, the pathogenesis of viral myocarditis has been unclear, which leads to the lack of its effective treatments.\n\nTo investigate the role of chemokines in pathogenesis of viral myocarditis, mRNA

expression for a panel of 19 chemokines learn more detected by RT-PCR in myocardial tissue of BALB/c mice that were inoculated intraperitoneally with coxsackievirus B3. Moreover primary cultured cardiac myocytes were infected with coxsackievirus B3 following extraction of RNA, from myocytes the expression of 19 chemokines was detected by by RT-PCR.\n\nOur results showed that there was much difference in the expression pattern of chemokines in myocardial tissue between infected mice with viral Rigosertib cost myocarditis and uninfected control mice. The expression of chemokines was varied significantly in clusters in myocardium post coxsackievirus B3 Infection. There were also complexity and imbalance in the change of the expression of chemokines. In the meantime, Coxsackievirus B3 infection also influenced the expression pattern of chemokines in cardiac myocytes in vitro. However the expression

of monocyte chemoattractant protein-1 alone was upregulated in cardiac myocytes post coxsackievirus B3 infection in the 19 detected chemokines.\n\nThe chemokine expression pattern changed in complexity and imbalance manner both in myocardium and in primary cultured cardiac myocytes after coxsackievirus B3 infection. Coxsackievirus 133 infection may start viral myocarditis by regulating the expression pattern of chemokines in cardiac myocytes. MCP-1 may be one of key chemokines in the initial stage of viral myocarditis.”
“In this article, space shift keying (SSK) modulation is used to study a wireless communication system when multiple relays are placed between the transmitter and the receiver. In SSK, the indices of the transmit antennas form the constellation symbols and no other data symbol are transmitted.

However, specific neuronal factors that may explain this resistance remain to be discovered. In a screen for antiviral factors using a fibroblast line chemically mutagenized and selected for resistance to retroviral infection, we recently identified induction of rat FEZ1 (fasciculation and elongation protein zeta-1), a brain-specific protein, as the cause of this resistance. When exogenously expressed in nonneuronal cell lines rat FEZ1 blocked nuclear entry of retroviral DNA. Here, we demonstrate that among human brain cells, neurons

naturally express Nocodazole mechanism of action high levels of FEZ1 compared to astrocytes or microglia cells and are correspondingly less susceptible to infection with pseudotyped HIV-1 that bypasses receptor-mediated viral entry. Demonstrating that endogenous FEZ1 was functionally important in the resistance of neurons to HIV-1 infection, siRNA-mediated knockdown of endogenous FEZ1 increased the infectivity of neurons while sensitive brain cell types like microglia became more resistant upon FEZ1 overexpression. In addition, FEZ1 expression was not induced in response

to IFN treatment. As such, in contrast to other widely expressed, IFN-inducible antiviral factors, FEZ1 appears to represent a unique neuron-specific determinant of cellular susceptibility to infection in a cell type that is naturally resistant to HIV-1.”
“The asymmetric unit of the title compound, C(13)H(11)IN(2)O, comprises two crystallographically independent molecules. The dihedral angles between the ring planes are 53.56 (9) and 72.14 (19)degrees CX-6258 clinical trial in the two molecules. Pairs of intermolecular N-H center dot center dot center dot N hydrogen bonds and I center dot center dot center

dot BVD-523 price O interactions link neighbouring molecules into two different pairs of dimers, those involving N-H center dot center dot center dot N interactions having R(2)(2)(8) ring motifs. Short intermolecular I center dot center dot center dot O [3.1458(15)angstrom] and I center dot center dot center dot N [3.4834 (16) A] contacts are present. The crystal structure is further stabilized by intermolecular C-H center dot center dot center dot pi interactions [3.565 (2) and 3.629 (2) angstrom].”
“Raw residual wood biomass, containing cellulose, hemicellulose and lignin, was liquefied at low temperature by ultrasound-assisted solvolysis and acidolysis by glycerol, diethylene glycol and p-toluenesulfonic acid. Liquefied biomass was consequently upgraded by hydrotreatment utilizing heterogeneous catalysis over NiMo/Al2O3 bifunctional catalyst. Effects of temperature (200-350 degrees C), heating rate (2.5-10.0 K min (1)), hydrogen/nitrogen pressure (2-8 MPa), mixing (250-1000 mm (1)), hydrogen donor solvent (tetralin) and catalyst contents on deoxygenation were established.

This article describes two patients, both on ventilatory support in the intensive care unit. Failure to recognize spontaneous aseptic-pneumoperitoneum can result in unnecessary laparotomy with its risks. Hence under relevant circumstances, non-surgical causes of pneumopreitoneum should be excluded.”
“BACKGROUND: Electrical status epilepticus during sleep is characterized by epilepsy, a specific electroencephalographic

pattern, and neuropsychological impairment. This study aims to evaluate the efficacy and safety of levetiracetam in treating children with electrical status epilepticus during sleep. METHODS: A multicenter, retrospective, open-label study enrolled 73 children (mean age: 8 years) affected by electrical status epilepticus Cyclopamine concentration during sleep. The efficacy was rated according to the seizure frequency and electroencephalography response. RESULTS: After

a mean treatment period of 19 months (range: 6 to 24 months), 33 (63.5%) of 52 patients became seizure-free or had experienced remarkable reduction in seizures. The electrical status epilepticus of 41(56.2%) of 73 patients disappeared off their electroencephalography. The electroencephalography efficacy of levetiracetam treatment was noted in the monotherapy (61.9%) and add-on (53.9%) groups. The clinical (67.7%) and electroencephalography (64.3%) response rates of the idiopathic group were better than those of the symptomatic group (57.1% and 45.2%, respectively). No patient discontinued selleckchem the trial because of intolerability of see more side effects. CONCLUSIONS: Levetiracetam is effective in individuals with electrical status epilepticus during sleep with tolerable side effects.”
“Background Tendinopathy is a clinical diagnosis of localised tendon pain often confirmed by imaging findings. The pathophysiological cause of the pain is unknown and the sympathetic nervous system (SNS) may be implicated. Objective To review what is known regarding the role of the SNS in human tendinopathy. Study selection Published data describing sympathetic innervation or an index of sympathetic activity

in human tendons were eligible for inclusion. Data sources Bibliographical databases (AMED, Biological Abstracts, CINAHL Plus, EMBASE, MEDLINE, Scopus, SPORTDiscus and Web of Science) were searched for relevant articles. Reference lists from included articles were screened for additional articles. Study appraisal Studies were scored with a quality assessment tool to identify potential sources of bias. Each question had an explicit decision rule to guide assessment. Results Nine case-control and four cross-sectional studies examined sympathetic innervation of tendons. There was evidence suggesting a lack of difference in sympathetic innervation of tendon proper between tendinopathy biopsies and healthy controls. In contrast, the paratendinous tissue showed evidence of increased sympathetic innervation in painful tendons.

The correlation times, activation energy, geometry of motion of benzene molecule and LY3023414 molecular weight pyridinium cation, isothermal compressibility, and activation volume obtained from the simulations are compared with the experimental results obtained by nuclear magnetic resonance and QENS methods. MD simulations have also revealed that reorientation of the pyridinium cation in pyridinium nitrate between two inequivalent positions is strongly affected by the hydrogen bond N-H center dot center dot center dot O between the cation and the anion and the influence of temperature on strength of the hydrogen bond is much more important than

that of the pressure. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4774096]“
“The influence of decorative and anticorrosive pigments on the distribution of pigments and protective properties of self-stratifying epoxy/acrylic coating systems was investigated. The separation of pigments was determined basing on their properties and the type of additives used and was expressed as a factor determining the separation of the pigments between the learn more upper and bottom layer. The pigment distribution coefficient was calculated basing on the colour difference between the upper and bottom layer as well as by means of the XRF method.\n\nThe results of investigations of self-stratifying

coatings in a salt spray chamber prove that such systems have comparable or even better corrosion protection properties compared to classical two-layered systems containing the same resins and pigments. The best adhesion to substrate, interlayer cohesion and pigment distribution were obtained in systems containing chrome oxide green and micaceous iron oxide. (C) 2011 Elsevier B.V. All rights reserved.”
“The agronomic practices such as nitrogen fertilizer and population density affect the plant vegetation pattern and cnopy structure and change the pathogenic activities through the microclimate variability generated as a result of these practices and thus modify the disease development. mTOR inhibitor A study was carried out in the field to investigate the effect

of three nitrogen rates (0, 150 and 300 kg ha(-1)) and three tiller densities (600, 120 and 30 tillers m(-2)) on the development of Septoria tritici on wheat variety Pastiche. The results revealed that nitrogen application increased the severity of S. tritici up to 150 kg ha(-1) but doubling this rate produced a slight reduction in the disease level on all leaves assessed both at growth stage (GS) 55 and GS 70 however, the difference was not significant. Increasing shoot density increased the development of S. tritici at GS 55which is attributed to a more favourable microclimate produced with in the leaf canopy at a higher tiller densities compared with produced at the lower tiller densities. However, a very small reduction was recorded at GS 70 at the highest density level when tiller density increased from 120 to 600 tiller m(-2).

The mRNA and protein expression of asymmetric dimethylarginine (ADMA) was increased and eNOS Belnacasan protein was decreased suggesting the involvement of this pathway in Hcy mediated hypertension. Decreased expressions of VEGF and increased anti-angiogenic factors, angiostatin and endostatin indicated impaired vasculogenesis. FA treatment partially reduced hypertension by mitigating HHcy in Ang II-treated animals and alleviated pro-inflammatory, pro-fibrotic

and anti-angiogenic factors. These results suggest that renovascular remodeling in Ang II-induced hypertension is, in part, due to HHcy.”
“Most literature on the relationship between video gaming and sleep disturbances has looked at children and adolescents. There is little research on such a relationship in adult samples. The aim of the current study was to investigate

the association of video game volume PKC412 molecular weight with sleep quality in adults via face-to-face interviews using standardized questionnaires. Adults (n=844, 56.2% women), aged 18-94years old, participated in the study. Sleep quality was measured using the Pittsburgh Sleep Quality Index, and gaming volume was assessed by asking the hours of gaming on a regular weekday (Mon-Thurs), Friday and weekend day (Sat-Sun). Adjusting for gender, age, educational level, exercise and perceived stress, results of hierarchical regression analyses indicated that video gaming volume was a significant predictor of sleep quality (=0.145), fatigue (=0.109), insomnia (=0.120),

bedtime (=0.100) and rise time (=0.168). LY2603618 price Each additional hour of video gaming per day delayed bedtime by 6.9min (95% confidence interval 2.0-11.9min) and rise time by 13.8min (95% confidence interval 7.8-19.7min). Attributable risk for having poor sleep quality (Pittsburgh Sleep Quality Index bigger than 5) due to gaming bigger than 1hday was 30%. When examining the components of the Pittsburgh Sleep Quality Index using multinomial regression analysis (odds ratios with 95% confidence intervals), gaming volume significantly predicted sleep latency, sleep efficiency and use of sleep medication. In general, findings support the conclusion that gaming volume is negatively related to the overall sleep quality of adults, which might be due to underlying mechanisms of screen exposure and arousal.”
“Aim: This study evaluated the safety and efficacy of influenza vaccination in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis. Methods: Thirty-one patients who were in remission were randomized to receive either a trivalent influenza vaccine or no vaccine. Vaccine efficacy was assessed at 28 days. Patients were followed for 6 months for signs of reactivation of disease. In addition, 67 healthy individuals were randomized to receive either the influenza vaccine or no vaccine to assess its potential for triggering the formation of autoantibodies.

The strength of the relationship between functional connectivity and see more cognitive control did not differ between groups. These results indicate that SUD is associated with abnormal interactions between subcortical areas that process reward (nucleus accumbens) and cortical areas that govern cognitive-behavioral control. Hum Brain Mapp 35:4282-4292, 2014. (C) 2014 Wiley Periodicals, Inc.”
“Background. Although mycophenolate mofetil (MMF) is recommended at a fixed dose, there is increasing interest in controlled-dose (CD) MMF based on therapeutic drug monitoring. We systematically evaluated published randomized controlled trials (RCTs) on the efficacy and safety of CD

versus fixed-dose MMF for kidney transplant recipients. Methods. The electronic databases Medline, Embase, and Cochrane Library (up to June 2012) were searched to identify relevant RCTs. Two reviewers independently applied the study selection criteria, examined the study quality, and extracted

the data. Dichotomous measures were expressed as relative risk (RR) and continuous outcomes were expressed as weighted mean difference, both with 95% confidence intervals (CIs). All statistical analyses were performed using Review Manager 5.1.6. Results. Four RCTs met our selection criteria and included 1755 de novo recipients. The differences between CD and fixed-dose MMF in treatment failure (RR, 0.95; 95% CI, 0.82-1.10; P=0.52), serum creatinine clearance (weighted mean difference, CP456773 2.46; 95% CI, -1.15 to 6.07; P=0.18), total gastrointestinal

adverse events (RR, 1.23; 95% CI, 0.65-2.35; P=0.53), diarrhea (RR, 1.08; this website 95% CI, 0.92-1.25; P=0.35), anemia (RR, 1.24; 95% CI, 0.95-1.64; P=0.12), leukopenia (RR, 1.12; 95% CI, 0.93-1.35; P=0.25), thrombocytopenia (RR, 0.80; 95% CI, 0.47-1.36; P=0.41), and malignancy (RR, 0.61; 95% CI, 0.27-1.38; P=0.23) were not statistically significant. Furthermore, total infections were more frequent in the CD group (36.0% vs. 30.9%; RR, 1.16; 95% CI, 1.03-1.30; P=0.01). Conclusions. Based on current evidence, CD MMF administration cannot be recommended as routine practice for kidney transplant recipients. Therapeutic drug monitoring for MMF may be targeted toward high-risk recipients, who should be identified in future studies.”
“The formation of mossy lithium and lithium dendrites so far prevents the use of lithium metal anodes in lithium ion batteries. To develop solutions for this problem (e.g., electrolyte additives), operando measurement techniques are required to monitor mossy lithium and dendrite formation during electrochemical cycling. Here we present a novel battery cell design that enables operando electron paramagnetic resonance (EPR) spectroscopy.

Logistic regression was used to investigate possible predictors of early response and the Bonferroni correction was applied.\n\nIn

the STAR*D, higher levels of baseline core depressive symptoms (Bech subscale) were associated with early response (p = 0.00017), as well as lower baseline insomnia (p = 0.003) and higher learn more work and social functioning (p = 0.001). In the Italian sample none of these variables were associated with the phenotype, but a non significant trend of lower baseline quality of life (p = 0.078) was observed in late remitters.\n\nIn the STAR*D late responders reported higher levels of antidepressant induced side effects, especially difficulty in sleeping (p = 5.68e-13), with a non significant trend in the same direction in the Italian sample (p = 0.09). The identification of late versus early antidepressant responders at the beginning of the treatment may be useful to guide therapeutic choices in clinical settings. (C) 2013 Elsevier Ltd. All rights reserved.”
“Alpha-1 antitrypsin (AAT) deficiency is a lethal hereditary disorder characterized by a severe diminution in plasma levels of AAT leading to progressive liver dysfunction. Since mesenchymal stem cells can differentiate into hepatocyte-like cells they offer a potential this website unlimited source in autologous transplant procedures. The transfer of genetically modified hepatocyte cells derived from hMSCs

into the body constitutes a novel paradigm of coupling cell therapy with gene therapy for this disease. hMSCs were isolated by density gradient centrifugation

and plastic adherence. Hepatic differentiation was induced by exposing hMSC to induction medium for up to 21 days. The mRNA levels and protein expression of several important hepatic genes were determined using RT-PCR and immunocytochemistry. The chimeric AAT-Jred transgene was transferred to differentiated cells using a lentiviral vector and its expression was visualized by fluorescent microscopy. Flow cytometric analysis confirmed that hMSCs were obtained. Major hepatocyte marker genes expression were confirmed by RT-PCR and immunocytochemistry. AAT gene was successfully introduced into hepatocyte-like cells CH5424802 in vitro differentiated from hMSCs. This established system could be suitable for generation of hMSC derived hepatocyte-like cells containing the normal AAT gene, thus offering a potential in vitro source of cells for transplantation therapy of liver diseases in AAT-deficient patients. (C) 2010 Elsevier Ltd. All rights reserved.”
“Jasrouxite, Ag16Pb4(Sb25As15) Sigma S-40(72), is triclinic, space group P-1, lattice parameters a = 8.2917(5), b = 19.101(1), c = 19.487(1) angstrom, alpha = 89.731(1)degrees, beta = 83.446(1)degrees, and gamma = 89.944(1)degrees. Unit-cell volume is V = 3066.1(3) angstrom(3), Z = 1 for the title formula.