Our study included 657 HCV infected patients with genotype 4 who received interferon-based combination therapy and according to response to therapy they were divided into two groups:356
as responders and 301 as non responders. They were compared to 160 healthy control persons. LDL receptors Exon8c.1171G>A and Exon10c.1413G>A were Cyclopamine in vitro assayed for all cases by real-time PCR-based assays. Correlation of LDL receptors polymorphism with HAI, META-VIR score, steatosis, and BMI were done to all cases. Results: There was no statistical significant difference in response rate between either different types of interferon used or LDL receptor Exon10c.1413G>A. However, there was statistical difference in frequency of LDL receptor Exon8c.1171G>A genotype between cases, control,responders and non responders. The G allele of LDL receptors Exon8c.1171G>A was predominant in cases find more and control than A allele and shows statistical significant association with response to interferon, so that carriers of A allele have 16.4 times risk for non response ( p<0.001). There was significant association between LDL receptors Exon8 c.1171G>A and HAI (<0.011). There was significant association between LDL receptors Exon8 c.1171G>A and BMI, where BMI mean level was highest in those carrying AA genotype. Again only significant association was found between LDL receptors Exon8 c.1171G>A and METAVIR score, steatosis (p<0.001) Conclusion: LDL receptor gene
polymorphism plays a role in the response of MCE the virus to treatment and in the modulation of disease progression in Egyptian population infected with chronic HCV. Frequency of the genotypes of LDLR gene polymorphisms in the studied groups: Disclosures: The following people have nothing to disclose: Mazen I. Naga, Mona A. Amin, Dina A. Algendy, Ahmed I. El Badry, Mai M. Fawzi, Ayman R. Foda, Serag M. Esmat,
Dina Sabry, Laila A. Rashed, Samia M. Gabal, Manal Kamal Introduction: Recent French report on viral hepatitis B and C recommended reinforced epidemiological surveillance, especially in populations with a high risk of infection. Prisoners are particularly affected by hepatitis B and C because of their behaviors, social status and isolation.This prospective study aimed to evaluate, in a population of incomers in French prisons, the prevalence and management of viral hepatitis and liver fibrosis. Patients and methods: HBV/HCV screening and a liver stiffness measurement with FibroScan (FS) were proposed to every incomer in prison, followed by a consultation of hepatology in case of a positive serology or a FS>7.1 kPa (significant fibrosis). Results: Between February 2012 and November 2013, 1791 incomers were included in 5 French prisons. Subject characteristics were: male 99%, mean age 32 years, BMI 23.5 kg/m2, drug injectors 7.5%, smokers 82%, opioid replacement therapy 11.3%, unemployed 38%, homeless 5%, first imprisonment 34.7%.