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“Human papillomavirus (HPV) infection has a well established association with the development of genital warts and many types of cancer, including cervical, anal, oropharyngeal, and penile cancer.[2,3] It is the most common sexually transmitted infection in the US, with an annual prevalence of 1% of the sexually BCKDHB active population. It has been estimated that 80% of sexually active women will acquire HPV infection by the time they are aged 50 years. Rates among men are also high, with estimates of ≈65–70% of males being infected with HPV. Young people appear to be most at risk, with 74% of annual HPV infections occurring in men and women aged 14–24 years. While most HPV infections are transient,[2,3] ≈10% lead to persistent infection. Approximately 40 of the >100 known HPV types have been shown to infect the anogenital tract.