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in well-trained wrestlers. J Sports Med Phys Fitness 2002, 42:330–339.PubMed 46. Steenge GR, Simpson EJ, Greenhaff PL: Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. J Appl Physiol 2000, 89:1165–1171.PubMed 47. Kerksick CM, learn more Wilborn CD, Campbell WI, Harvey TM, Marcello BM, Roberts MD, Parker AG, Byars AG, Greenwood LD, Almada AL, et al.: The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations. J Strength Cond Res 2009, 23:2673–2682.PubMedCrossRef 48. Dash AK, Sawhney A: A simple LC method with UV detection for the analysis of creatine and creatinine and its application to several creatine formulations. J Pharm Biomed Anal 2002, 29:939–945.PubMedCrossRef Competing interests AlzChem AG (Trostberg, Germany) provided funding for this study NVP-HSP990 through a research grant to Texas A&M University. All researchers involved independently collected, analyzed, and interpreted the results from this study and have no financial interests concerning the outcome of this investigation. RBK has received grants as Principal Investigator through institutions

with which he has Thiazovivin in vitro been affiliated to conduct exercise and nutrition related research, has served as a legal and scientific consultant, and currently serves as a scientific consultant for Woodbolt International (Bryan, TX). Remaining coauthors have

no competing interests to declare. Data from this study have been presented at the International Society of Sports Nutrition Annual meeting and have not been submitted for publication to any other journals. Publication of these findings should not be viewed as endorsement by the investigators or their institutions of the nutrients investigated. Authors’ contributions ARJ served 6-phosphogluconolactonase as the study coordinator, oversaw all testing, and assisted in data analysis and writing of the manuscript. JMO assisted in data collection and statistical analysis. AS assisted with data collection. EG assisted with data collection and reviewed and approved nutritional records as the studies’ registered dietitian. JF and SR supervised the biopsy procedures. MG assisted in experimental design, data analysis, and manuscript preparation. KK supervised muscle assays and CM served as a collaborating scientist. CR served as lab coordinator and oversaw data collection and quality control of the study. RBK served as Principal Investigator and contributed to the design of the study, statistical analysis, manuscript preparation, and procurement of external funding. All authors read and approved the final manuscript.