This journal is a The Royal Society of Chemistry Downloaded by New York University on 0 March Published on 8 February on | View Online Table Neutral red andet assays with genotoxins and the Danube River sediment extracts from Opgen and Sigmaringen. GeneTEQs are given in relation to the maximum tail moment for MNNG in theet assay after 4 h and 8 h of Everolimus exposu respectively.
Standard deviations are given in brackets after 4 h of exposure GeneTEQs after 8 h of exposure ,mg SEQ In the present stu MNNG was ally selected as the referencepound for the GeneTEQ approach on the basis of Hordenine inhibitor purely scienti considerations. It shou howev be kept in mind that there is evidence for carcinogenicity of MNNG and that particular care should be taken for handling. 6 Genotoxicity and GeneTEQs of other pure substances and the sediment extracts In theet ass C DMNA and MNU showed only minor effects . In RTL cel for none of these substances a clear and reproducible concentration “response curve was found.
The effects of CPP and DMNA were clearly below the 0 effect level of MNNG. Th no tovok 439081182 EC x MNNG values could be calculated for CPP and DMNA. Howev by using the tail moment for MNU a GeneTEQ 0 of in relation to the MNNG effect after 8 h could be calculated . For percent tail D the value was even lower . Th regarding the tail mome at the level buy Genistein of 0 of the maximum MNNG effe mg MNNG had the same genotoxic effect as mg MNU. Th at the effect level of 0, MNNG was 0fold more genotoxic than MNU. All test concentrations $ mg L NQO showed signi ant differences from the negative control. Induction factors wereparably low with a maximum of . A concentration “response relationship could not be observed. At the level of EC 0MNN GeneTEQs were calculated for NQO .
Genotoxicity ofmethylN nitroN nitrosoguanidine after 4 h and 8 h in theet assay with RTL cells. Data are given as box plo displaying the following percentiles. Central solid lines represent medians. Asterisks indicate signi ant genotoxic effects . For each concentrati induction factors are given organizing center above the boxes. NC negative controls; PC positive controls . This journal is a The Royal Society of Chemistry Fig. Logarithmiz interpolated EC x values for tail moment data of MNNG related to the maximum MNNG effect and delogarithmized EC x values after 4 h and 8 h of exposure in theet assay with RTL cells. J. Environ. Monit. Downloaded by New York University on 0 March Published on 8 February on . View Online Table et assay with genotoxins and the Danube River sediment extracts from Opgen and Sigmaringen. GeneTEQs are given in relation to the maximum percentage of tail DNA.