Diosmin regnancy to reduce breast cancer risk. J Natl Cancer Inst  Lukanova A, Surcel Lundin E, Kaasila M, Lakso Schock H, Circulating estrogens and progesterone during primiparous pregnancies and risk of maternal breast cancer. Int J Cancer.  Downloaded from clincancerres.aacrjournals on March  Copyright American Association for Cancer Research Author Manuscript Published OnlineFirst on March   Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Figure Legends Figure . Tamoxifen and letrozole dose finding studies Treatment with tamoxifen and letrozole showed a statistically significant survival benefitpared to controls . For tamoxif for control and for each dose lev and for letrozo all groups.

MMT tumors and a derived cell line expressed ER and , as determined by Western blot Cabozantinib VEGFR-PDGFR inhibitor analysis . MCF cell lysates serve as a positive control while  actin served as loading control. Figure . Serum cytokine levels in vaccinated MMT females versus placebo/untreated and  treated mice. Whole blood was collected via submandibular bleeds hours after the t th and th dose of vaccine or placebo. Whole blood was pooled within each treatment group and serum was analyzed using Luminex technology. The levels of IFN were noticeably higher in vaccinated vslacebo treated mice at all time points. IL levels in vaccinated vslacebo treated mice were not noticeably different at any time point. Serum levels of IL appeared to be higher in all vaccinated mice vslacebo treated mice. Concentration values are means of duplicate samples and error buy masitinib bars represent the range. Missing bars represent values below detection limits.

Representative serum cytokine responses following hormonal therapy in vaccinated and unvaccinated mice. Whole blood was collected via submandibular bleeds hours after the rd and th dose of vaccine and pooled for each treatment group . The levels of IFN were higher in all vaccinated mice regardless of treatment. No Downloaded from Phloridzin inhibitor clincancerres.aacrjournals on March  Copyright American Association for Cancer Research Author Manuscript Published OnlineFirst on March   Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. obvious changes in levels of IL were noted in vaccinated micepared to unvaccinated mice. Concentration values are means of duplicate samples and error bars represent the range. Missing bars represent values below detection limits. Figure . Representative cytokine patterns in hormonally treated vaccinated and unvaccinated mice. Mice were euthanized hours after the th dose of vacci and serum was analyzed for cytokines. Vaccinated mi regardless of treatme had elevated IFN and IL leve which are indicative of a T immune response.

Although levels of the T  associated cytokines IL and IL were elevated in some vaccinated hydrazine mi on balance the predominant immune response was T polarized as evidenced by the strong IFN and IL responses. Concentration values are means of duplicate samples and error bars represent the range. Missing bars represent values below detection limits. Figure . Detection of MU specific splenocytes by ELISpot assay in hormonally treated vaccinated and unvaccinated mice.