So tumor cells are more vulnerable to the damage effects of chemotherapy, especially when the cytotoxic drug is administered at a low dose[15, 16]. Therefore, a coordination approach targeting multiple tumor-associated
cell properties seems to be a promising strategy for marked inhibition of tumor growth[15, 17–19]. In summary, our results in the current research indicate that the combination of antiangiogenesis gene therapy with low-dose chemotherapy learn more was more effective to suppress tumor growth without obvious toxicity in mice than either agent alone. The mechanism may in part concern the increased induction of apoptosis and suppression of angiogenesis in the combination treatment. To our knowledge,
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