Raw data were filtered using Quintic Spline functions based on Woltring��s CGV method for calculating the smoothing factor (Woltring, 1986). Procedures After a specific warm-up, 15 Ivacaftor 873054-44-5 left trials and 15 right trials at their natural speed were randomly captured from the subject. If the participant did not introduce the ball into the goal area, the trial was rejected. The ball was placed by the subject approximately 1.5 to 2 metres away from the centre of the calibrated area. The drag-flick movement commenced 20 frames before the right foot contacted the floor and continued until 20 frames after the ball release. The ball velocity at release was obtained. The pelvis, upper trunk, and stick angles were calculated considering the line of the double foot contact as the Y-axis, the X-axis 90�� from the Y-axis to the right and the Z-axis as the vertical axis.

Angular velocities at clockwise were considered as negatives, and those at anticlockwise were considered positives (Figure 1). The angles were computed with the line formed by the upper trunk (shoulder line), pelvis (hip line), and stick with the X-axis on the XY plane. The knee flexion angle was registered for the front leg only. Some kinematic events of the drag-flick were identified, with the corresponding time periods: T1 (front foot heel contact), T2 (maximum angular velocity of the pelvis), T3 (minimum angular velocity of the stick), T4 (maximum angular velocity of the upper trunk), T5 (maximum angular velocity of the stick), T6 (release of the ball) and T7 (maximum velocity of the ball).

The event times were normalised considering T1 as 0% and T6 as 100%. The stance width, drag-flick length, front foot-ball distance at T1 and T6, and hip line midpoint-shaft head distance at T1, T3 and T6 were obtained and normalised to the player��s body height. Figure 1 Y-axis and X-axis location in the experimental space of the Biomechanics Laboratory Statistical Analysis Statistical analysis was carried out using SPSS v.15 software (SPSS Inc., Chicago, IL, United States). Means and standard deviations of the study were calculated. Comparison of means between independent groups (right and left trials) was used (U Mann-Whitney). The effect size was calculated using Cliff��s Delta test (Macbeth et al., 2011). The alpha level of significance was set at p<0.05 for all statistical tests.

Results The ball velocity at release did not differ between the right (22.20 �� Drug_discovery 0.80 m/s) and left drag-flicks (22.49 �� 0.68 m/s). During the front heel contact with the floor, as shown in Table 1, the stick position of the right drag-flicks was significantly behind (Z=2.06; p<0.05) the stick position of the left ones. Table 1 Significant Differences between Right and Left Drag-Flicks (Mean �� Standard Deviations) At double foot contact (T1), the distance between the front foot and the ball, and the distance normalised to the player��s body height, were significantly longer (Z=2.34; p<0.