Electron microscopy demonstrated that GLP-2 treatment increased number and length of Microvillus of the epithelial cells. The

expression of PCNA in GLP-2 treatment group is obviously higher than transplantation group in intestinal villous and crypt. What’s more, the expression of PCNA in crypts is more apparent. Conclusion: GLP-2 supplementation can stimulate the proliferation and promote ultrastructure recovery of Intestine mucosal cell following congestion–reperfusion injury. Our studies promote the current level of understanding of the molecular determinants of GLP-2 and the patients of LT can get benefits from this research results. Supported by the National Nature Science Foundation of China Decitabine ic50 No. 81370583, No. 30801127; Liaoning BaiQianWan Talents Program No. 2013921053; Liaoning Provincial Natural Science Foundation of China INK128 NO.2014. Key Word(s): 1. liver transplantation; 2. glucagon-like peptide-2; 3. congestion-reperfusion injury; 4. electron microscopy; 5. PCNA Presenting Author: ZULKHAIRI

ZULKHAIRI Additional Authors: HERRY ADLIN, TARIGAN ELIAS, HAKIM ZAIN LUKMAN Corresponding Author: ZULKHAIRI ZULKHAIRI Affiliations: Adam Malik General Hospital Medan, Adam Malik General Hospital Medan, Adam Malik General Hospital Medan Objective: Liver biopsy is the recognized gold standard for liver fibrosis staging but t his procedure is invasive, and has known adverse events and limitations. A great interest has been dedicated to the development

of noninvasive predictive models in recent years to liver biopsy. The aspartate aminotransferase to platelet ratio index (APRI) has been proposed as a noninvasive and readily available tool for the assessment of liver fibrosis in chronic hepatitis C and medchemexpress B (CHC & B). This study aimed to evaluate the diagnostic usefulness of APRI in CHC & B, in a North Sumatera provinsional general hospital setting. Methods: Cross sectional study in 71 patients confirmed with Hepatitis B and C in Adam Malik General Hospital Medan Indonesia had liver biopsy from January 2011 to September 2013. Fibrosis was staged according to the METAVIR scale. Examination of AST and Platelet was done to fulfill the APRI score. Predictive value and AUROC were constructed to assess the accuracy of APRI compared with METAVIR scale. Results: Predictive value for APRI index (cut off > 1,5) to METAVIR scale in diagnose severe fibrosis is: sensitivity 42,4%, Specifity 73,7%, positive predictive value (PPV) 58,3%, negative predictive value (NPP) 59,6%, LR (+) 1,61 and LR (-) 0,78. Accuracy diagnostic is 59,1%, AUROC 0,581 (95% CI:0,446-0,715) with p < 0,005. Conclusion: APRI can be used to assess the degree of fibrosis in chronic hepatitis C and B patients. Key Word(s): 1. APRI; 2.