We performed multiple logistic regression to study factors associated with the use of high-dose antihypertensive medication. We performed subgroup analyses according to sex (men vs. women), age (≥55 years vs. <55 years), body mass index (≥25 kg/m² vs. <25 kg/m²),
and the presence and absence of isolated https://www.selleckchem.com/products/amg510.html systolic hypertension (systolic blood pressure ≥160 mmHg and diastolic blood pressure <90 mmHg), diabetes mellitus, and chronic kidney disease. 3 Results 3.1 Patient Characteristics Of the 632 screened patients, 501 were enrolled in the study and started treatment with irbesartan/hydrochlorothiazide 150 mg/12.5 mg once daily. During the 12-week study treatment period, 52 patients (10.4 %) were withdrawn because they withdrew their consent (n = 18, 3.6 %), did not follow the study protocol (n = 5, 1.0 %), because of adverse events (n = 13, Anlotinib supplier 2.5 %), or other reasons (n = 16, 3.2 %). In total, 449 patients completed
the 12-week study follow-up. Table 1 shows the baseline characteristics of the 501 patients by sex [264 (52.7 %) were women]. Compared with the women, the men were A-1210477 slightly younger (−1.8 years; p = 0.03), had lower systolic blood pressure (−1.9 mmHg; p = 0.05), had higher diastolic blood pressure (+3.0 mmHg; p < 0.0001) and hence narrower pulse pressure (−4.9 mmHg; p < 0.0001), and included more users of antihypertensive drugs (p = 0.02) and antidiabetic drugs (p = 0.03). However, the men and women were similar in most baseline characteristics such as the body mass index; pulse rate; presence of diabetes mellitus, dyslipidemia, or chronic kidney disease; previous history of stroke; and previous use of specific classes Non-specific serine/threonine protein kinase of antihypertensive drugs (p > 0.05). Table 1 Baseline characteristics of the patients included in the intention-to-treat analysis Characteristic Men (n = 237) Women (n = 264) p value Age (years; mean ± SD) 54.1 ± 9.8 55.9 ± 8.6 0.03 Body mass index (kg/m2; mean ± SD) 25.8 ± 3.1 25.7 ± 3.5 0.77 Systolic blood pressure (mmHg; mean ± SD) 161.5 ± 11.3 163.4 ± 10.0 0.05 Diastolic blood pressure (mmHg; mean ± SD) 99.5 ± 8.6
96.5 ± 8.4 0.0001 Pulse rate (beats/min; mean ± SD) 74.7 ± 9.7 74.1 ± 10.1 0.46 Previous or concomitant disease [n (%)] Strokea 3 (1.2) 1 (0.4) 0.27 Coronary heart diseaseb 5 (2.1) 14 (5.3) 0.06 Arrhythmiac 12 (5.1) 9 (3.4) 0.36 Dyslipidemiad 4 (1.7) 9 (3.4) 0.23 Diabetes mellituse 35 (14.8) 50 (18.9) 0.21 Chronic kidney diseasef 77 (32.5) 98 (37.1) 0.28 Previous treatment [n (%)]g Antihypertensive treatment 117 (49.4) 158 (59.9) 0.02 Calcium channel blockers 52 (21.9) 70 (26.5) 0.23 Angiotensin-converting enzyme inhibitors 29 (12.2) 32 (12.1) 0.97 Angiotensin receptor blockers 27 (11.4) 25 (9.5) 0.48 β-Blockers 5 (2.1) 11 (4.2) 0.19 Diuretics 5 (3.0) 9 (3.4) 0.38 Other antihypertensive drugs 12 (5.1) 27 (10.2) 0.03 Aspirin 4 (1.7) 3 (1.1) 0.60 Statins 1 (0.4) 1 (0.4) 0.