Validity: Several publications have indicated that there are only low correlations between walking distance and VO2max in children. The following Pearson’s correlations between 6MWT distance and VO2max are reported: juvenile idiopathic arthritis, r = 0.25; hemophilia, r = 0.31; spina bifida, r = 0.46; end-stage renal disease, r = –0.25. Recently it was reported that in children with pulmonary hypertension correlation between 6MWT distance

and VO2max was significant when the walk distance is lower than 300 m, and there was no association when the 6MWT distance was > 300 m ( Lammers et al 2011). Because of these low correlations, the 6MWT cannot be used as a replacement for a maximal exercise test ( Takken, 2010). Cyclopamine chemical structure The 6MWT is an inexpensive instrument for measuring functional exercise capacity in paediatric populations. Care should be taken to ensure Proteasome inhibitors in cancer therapy appropriate execution of the test. Our experience from a recent unpublished survey among Dutch (paediatric) physiotherapists is there is a large variety in performance of the 6MWT among therapists, especially distance between turning points (variation 5–50 metres), lay-out of circuit (circle, squares, and even on treadmill), instructions for turning, as well as differences in encouragements. For optimal reliability

it is important that the test is performed in a standardised manner as recommended by the ATS (ATS, 2002). Furthermore, the various sets of reference values differ substantially. Therefore, it is advised to use the same Linifanib (ABT-869) set of norm values all the time. “
“The International Standards for Classification of Spinal Cord Injury (ISCSCI) are widely used to classify the type and extent of a spinal cord injury (SCI) (American Spinal Injury Association 2003). The standards are based on comprehensive sensory and motor tests and are used to

derive right and left sensory and motor levels. Sensory and motor deficits can be summarised by tallying scores in different ways. For example, strength deficits in the upper limbs can be summarised by tallying the results of the upper limb motor tests (maximal score is 50). Importantly, the sensory and motor tests are also used to classify the type of spinal cord injury using the American Spinal Injury Association Impairment Scale (AIS). The important feature of the AIS is its definitions of complete and incomplete SCI. An SCI is only classified as incomplete if there is some sensory or motor function in the S4/5 segments, ie, if a person has anal sensation or the ability to voluntarily contract the anal sphincter. Validity and Reliability: The ISCSCI has good face validity because they were developed by expert and international consensus over a 20-year period. The Standards have two components: the physical examination and the classification.