Transcatheter arterial chemoembolization (TACE) was important treatment method, and stereotactic conformal radiotherapy (SCRT) was also used in unresectable HCC. In this study, the clinical application and therapeutic effects of TACE combined with and SCRT were evaluated on patients with advanced unresectable HCC. Methods: Forty-five patients with advanced unresectable HCC hospitalized from

February 2009 to February 2011 received the treatment of TACE combined with SCRT. Firstly, these patients were treated by two or three time procedure TACE. For TACE, 5-fluorouracil (1000–1500 mg) and cisplatin (60–80 mg) were perfused into the hepatic arteries, then mitomycin C (20 mg) and iodized oil (10–20 ml) were mixed and were given to emobolized compound screening assay the hepatic arteries. Secondly, SCRT were applied

on these cases. For SCRT, gamma knife stereotaxis radiation therapy was carried out. There were planning of treatment from 3 to 10 dots, 3–6 Gy per-fraction, 5 times per week, and the total treatment dose was 30–50 Gy. ≥50% isodose include PTV. The tumor size and serum AFP level were observed at per-3 months after combination treatment. The 1-, 2-year survival rates of the patients were analyzed. Results: Mean serum AFP level was significant decreased from 1824.0 ng/L to 212.6 ng/L. The average diameter of tumor before and after combination treatment were (7.21 ± 2.12)cm and (4.12 ± 1.53)cm. The survival rate of 1 and 2-year were 75.6% and 51.1% respectively. Conclusion: TACE AG-14699 combined with SCRT is effective for advanced unresectable HCC. Further clinical study on the

combination application of TACE with SCRT is needed. Niclosamide Key Word(s): 1. HCC; 2. TACE; 3. radiotherapy; Presenting Author: RAMIN ATAEE Additional Authors: ATEFEH ASEMI, MOHAMMAD SHOKRZADE, AMIN ATAEE Corresponding Author: RAMIN ATAEE Affiliations: Pharmaceutical Sciences Research center; Department of Pharmacology Objective: Melatonin is an important hormone which has important role in in circadian rhythm of human body, recently it has been cleared that it can have important role in regulating of some physiologic and pathological conditions especially cancer prevention though its’ role in inhibiting of breast and colon cancer has been confirmed but its’ role in gastric cancer is poor understood and this study aimed to show this role in gastric cancer Methods: For in vitro study we have used AGS adenocarcinoma cell line cultured in 96 wells (10000 cells in each well in 96 cultureplate) and also for proliferation assay we used MTT Elisa Method and for apoptosis we used TUNEL in-situ fluorescent microscopic assay. Also for each MTT and TUNEL assay, 5 concentrations of melatonin (200,100,50,25,12.5,6.