Three hundred twelve patients were retrospectively interrogated with a questionnaire 23.06 +/- 14.33 months after spontaneous subarachnoid hemorrhage. The modified Rankin scale (mRS) was determined, respectively. Scheduled PCT data sets from the first days after ictus were available for all patients.

The maximum mean transit time over several examinations per hemisphere (MTTPEAK) values were significantly correlated (p a parts per thousand currency signaEuro parts per thousand 0.001, r = 0.422) with the clinical long-term outcome GDC-0449 in vitro (mRS). Corresponding to our linear regression analysis, MTTPEAK is the second most important regressor (behind clinical severity of the initial hemorrhage) for the prediction of long-term

mRS. check details An MTTPEAK threshold of 3.98 s (identified by receiver operating characteristic analysis, area under the curve = 0.75) predicted an unfavorable long-term outcome (mRS a parts per thousand yenaEuro parts per thousand 2) with a sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of 67.3, 74.3, 84.5, 52.1, and 69.6 %, respectively.

The

presented data corroborate the relevance of PCT data for the clinical long-term outcome of SAH patients. By identification of patients who are at risk for a bad outcome and may need escalation of therapy, risk-benefit analysis is supported.”
“The goal of this study was to radiologically describe the anatomical characteristics of the cisterna magna (CM) with regard to presence, dimension, and configuration.

In this retrospective study, 523 records were reviewed. We defined five CM types, the range of which covered all normal variants found in the study population. Characteristics of the

CM were recorded and correlations between various posterior fossa dimensions and CM volume determined.

There were 268 female (mean age 50.9 +/- 16.9 years) and 255 male (mean age 54.1 +/- 15.8 years) patients. CM volume was smaller in females than in males and correlated with age (Pearson correlation, r = 0.1494, p = 0.0006) and gender (unpaired t test, r (2) = 0.0608, p < 0.0001). Clivus length correlated with CM volume (Pearson correlation, r = 0.211, p < 0.0001) and gender BAY 11-7082 mw (unpaired t test, r (2) = 0.2428, p < 0.0001). Tentorial angle did not correlate with CM volume (Pearson correlation, r = -0.0609, p < 0.1642) but did correlate with gender (unpaired t test, r (2) = 0.0163, p < 0.0035). The anterior-posterior dimension of cerebrospinal fluid anterior to the brainstem correlated with CM volume (Pearson correlation, r = 0.181, p < 0.0001) and gender (unpaired t test, r (2) = 0.0205, p = 0.001).

The anatomical description and simple classification system we define allows for a more precise description of posterior fossa anatomy and could potentially contribute to the understanding of Chiari malformation anatomy and management.