The strong positive correlation between ADMA and LnPTH, validated by the regression analysis, may suggest a link
between ADMA and PTH-derived vascular damage. ADMA levels could be influenced by the severity of hyperparathyroidism and contribute to cardiovascular death linked to PTH of hemodialysis patients.”
“Systems biology approaches to epidemiological studies of complex diseases include collection of genetic, genomic, epigenomic, and metagenomic data in large-scale epidemiological VX809 studies of complex phenotypes. Designs and analyses of such studies raise many statistical challenges. This article reviews some issues related to integrative analysis of such high dimensional and inter-related datasets and outline some possible solutions. Selleck DAPT I focus my review on integrative approaches for genome-wide genetic variants and gene expression data, methods for joint analysis of genetic and epigenetic variants, and methods for analysis of microbiome data. Statistical methods such as mediation analysis, high-dimensional instrumental variable
regression, sparse signal recovery, and compositional data regression provide potential frameworks for integrative analysis of these high-dimensional genomic data. (C) 2013 Wiley Periodicals, Inc.”
“Background: In patients with anomalous left coronary artery from the pulmonary artery (ALCAPA) left ventricular (LV) dilatation and dysfunction evolves due to diminished myocardial perfusion caused by coronary steal phenomenon. Using late gadolinium enhanced cardiovascular magnetic
resonance (LGE-CMR) imaging, myocardial scarring has been shown in ALCAPA patients late after repair, however the incidence of scarring before surgery and its impact on postoperative course after surgical repair remained unknown.
Methods: 8 ALCAPA-patients (mean age 10.0 +/- 5.8 months) underwent CMR before and early after (mean 4.9 +/- 2.5 months) coronary reimplantation procedures. GSK1120212 concentration CMR included functional analysis and LGE for detection of myocardial scars.
Results: LV dilatation (mean LVEDVI 171 +/- 94 ml/m(2)) and dysfunction (mean LV-EF 22 +/- 10 %) was present in all patients and improved significantly after surgery (mean LVEDV 68 +/- 42 ml/m(2), p = 0.02; mean LV-EF 58 +/- 19 %, p < 0.001). Preoperative CMR revealed myocardial scarring in 2 of the 8 patients and did not predict postoperative course. At follow-up CMR, one LGE-positive patient showed delayed recovery of LV function while myocardial scarring was still present in both patients. In two patients new-onset transmural scarring was found, although functional recovery after operation was sufficient. One of them showed a stenosis of the left coronary artery and required resurgery.
Conclusions: Despite diminished myocardial perfusion and severely compromised LV function, myocardial scarring was preoperatively only infrequently present.