The prescriptions were obtained from patients handbooks that were took into hospital at the Medical Clinic Sector and also from prescriptions destined to AIDS patients that were in treatment at Hospital Universitario/CG-UFMS. The quali-quantitative study was conducted from August/2007 to May/2008 and 258 prescriptions were analised. Two hundred and thirty antimicrobials were prescribed, especially cefalosporins, fluorquinolons, buy Quizartinib glicopeptides and glycosamines. For AIDS patients 171 antimicrobials were prescribed, the majority being sulphas, antifungic and macrolides. The number of antimicrobials per patient was reduced relatively.

Among RUM indicators, warnings and instructions about the usage showed high rates of absence in prescriptions. It was noticed that at the Medical Clinic Sector the broad-spectrum antimicrobials were more frequently used.”
“Acid hydrolysis of 6-amino derivatives of 1,3,7-triazapyrene affords the corresponding

6-oxo-6,7-dihydro-1,3,7-triazapyrenes. In the case of 6,8-bis(dialkylamino)-1,3,7-triazapyrenes depending on their structure products of hydrolysis of one or two dialkylamino groups are obtained. 6-Alkoxy-8-dialkylamino-1,3,7-triazapyrenes were synthesized. Conditions were found providing a possibility to cleave an ether bonds in the presence of amino group in the 1,3,7-triazapyrene structure and also to perform the hydrolytic substitution of both functional groups.”
“Henoch-Schonlein purpura Selleck AMN-107 ( HSP) is an IgA-mediated small vessel vasculitis with a predominant cutaneous involvement. We assessed adult patients with HSP to identify the clinical and histopathological features and evaluate predictive factors of relapse. We reviewed the records

of 29 adult patients with HSP who presented at our department between 2002 and 2009. Adult HSP was confirmed by skin biopsy showing leukocytoclastic vasculitis and direct immunofluorescence showing IgA deposit. Among the 29 patients (15 men, 14 women; mean age 36.2 years old), renal involvement was initially learn more found in 22 patients (75.9%). They were divided into 2 groups according to the presence or absence of relapse. We compared clinical and histopathologic differences between 15 patients with relapse and 14 patients without relapse. By univariate analysis, older age at onset, persistent rash, abdominal pain, hematuria, and underlying disease at the onset of HSP are significantly related to relapse. Among the histopathological variables, severity of leukocytoclasis and absence of IgM deposit on the vessel walls are significantly associated to relapsing disease (P < 0.05). Our results are significant, because, they may help to understand the predictive factors related to relapses of HSP in adults.