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“The objectives of this research were to prepare celecoxib proniosomes and evaluate the influence of proniosomal formulation on the oral bioavailability of the drug

in human volunteers. Anew proniosomal delivery system for a poorly water-soluble drug such as celecoxib was developed and subjected to in vitro and in vivo studies. Proniosomes were prepared by sequential spraying method, which consisted of cholesterol, span 60, and dicetyl phosphate in a molar ratio of 1:1: 0.1, respectively. The average entrapment percent of celecoxib proniosome-derived niosomes was about 95%. The prepared proniosomes showed marked enhancement in the dissolution of celecoxib as compared to pure drug CB-5083 powder. The bioavailability of 200 mg single dose of both celecoxib proniosomal formulation and a conventional marketed celecoxib Selleck Ipatasertib capsule was studied in human volunteers. The obtained results show that the proniosomal formulation significantly improved the extent of

celecoxib absorption than conventional capsule. The mean relative bioavailability of the proniosomal formulation to the conventional capsule was 172.06 +/- 0.14%. The mean T(max) for celecoxib was prolonged when given as proniosomal capsule. There was no significant difference between the values of K(el) and t(1/2) for both celecoxib preparations. In conclusion, the proniosomal oral delivery system of celecoxib with improved bioavailability was established.”
“Dicyandiamide (DICY)-cured epoxy resins are important materials for structural adhesives and matrix resins for fiber-reinforced prepregs. Dynamic differential scanning calorimetry (DSC) with heating rates

of 2.5, 5, 10, and 15 degrees C/min was used to study the curing behavior of the epoxy prepreg Hexply 1454 system, which consisted of diglycidyl ether of bisphenol A, DICY, and Urone reinforced by glass fibers. The curing kinetic parameters were determined with three different methods and compared. These were the Kissinger, Ozawa, and Borchardt-Daniels kinetic approaches. The lowest activation energy (76.8 kJ/mol) was obtained with the Kissinger GSK2245840 method, whereas the highest value (87.9 kJ/mol) was obtained with the Borchardt-Daniels approach. The average pre-exponential factor varied from 0.0947 x 10(9) to 2.60 x 10(9) s(-1). The orders of the cure reaction changed little with the heating rate, so the effect of the heating rate on the reaction order was not significant. It was interesting that the overall reaction order obtained from all three methods was nearly constant (congruent to 2.4). There was good agreement between all of the methods with the experimental data.