The mutation process is initiated by the enzyme activation-induced cytidine deaminase (AID) [39] and there is, for example, evidence of AID expression by B cells at mucosal surfaces [40]. Intestinal helminths could perhaps DMXAA datasheet drive proliferation and mutation of IgE-committed B cells within these tissues, giving rise to antibodies of low affinity or even of uncertain specificity. A number of studies have reported that the specific IgE response is accompanied by an approximately 10-fold

higher production of non-specific or ‘bystander’ IgE [41, 42]. The source and molecular features of this non-specific response have not been reported, but it has been suggested that ‘bystander’ IgE arises through non-cognate interactions between activated T cells and antigen non-specific B cells [41]. This hypothesis is not consistent with the patterns of mutation seen in the IgE sequences in this study. On the other hand, an essentially random mutation process and the accumulation of IgE-switched B cells of lower find more affinity

or even of altered specificity offers an alternative explanation for the phenomenon of ‘bystander’ IgE that is consistent with the mutational evidence. If we are to understand the efficacy of these antibodies, and if we are to harness the IgE response, through vaccination, against those parasite infections that remain a burden on the health of much of the world’s people, Lck the biological processes that lead to these patterns of mutation must be explored. This work was supported by a grant from the National Health and Medical Research Council. We thank Kate McGill of the Immunopathology Department, St Vincent’s Pathology, St Vincent’s Hospital Sydney, for performing the serology tests.

We thank Sauli Bebes and the people of Masilakaiufa village for their assistance and participation in this study. “
“Hypogammaglobulinaemia (HGG), defined as a serum immunoglobulin G (IgG) level < 700 mg/dl, is a known complication of solid organ transplantation (SOT), with a high prevalence reported following heart, lung and kidney transplantation [1, 2]. HGG is associated with an increased risk of infection, which depends upon the degree of HGG, the type of allograft and the intensity of immunosuppression [1, 2]. Although all agents used for maintenance immunosuppression have a direct effect on T cell function and an indirect effect on B cell function and lymphokine production, some immunosuppressive agents (e.g. mycophenolate mofetil) have a more potent inhibitor effect on B lymphocyte proliferation and antibody production and may result in more pronounced HGG [1, 3]. HGG can occur following induction therapy, maintenance immunosuppressive regimens or treatment of rejection episodes [1].