The correlation of MGd1-Ag and clinical parameters of gastric cancer patients was analyzed, and the role of MGd1-Ag in predicting the prognosis of gastric cancer was also studied. Trametinib price Results: Positive staining of MGd1-Ag was found in normal lung tissue, hematopoietic cells, esophageal squamous epithelial surface, colonic epithelium, mucus glands of the salivary glands, basal cell of
skin and few glandular lumens of breast tissue. Gastric, colorectal, pancreatic, and lung cancers showed abundant distribution of MGd1-Ag. It was positive in several cases of intestinal metaplasia and atypical hyperplasia tissues. The expression density of MGd1-Ag was significantly higher in gastric cancer of such situations including poor differentiation, advanced TNM staging and lymph node metastasis. The total positive rate of MGd1-Ag was 81.8% in gastric cancers. Kaplan-Meier
SB203580 clinical trial analysis and Log-rank test showed that increased MGd1-Ag expression in gastric cancer patients associated with poor outcomes. Conclusion: MGd1-Ag was specifically expressed in gastrointestinal cancers. It was increased in intestinal metaplasia and atypical hyperplasia, and, in gastric cancer, was correlated with grades of differentiation, TNM staging and lymph node metastasis. Increased MGd1-Ag expression in gastric cancer patients associated with poor outcomes. Key Word(s): 1. Gastric cancer; 2. Early diagnosis; 3. MGd1-Ag; 4. Prognosis; Presenting Author: RAVINDRA SATARASINGHE Additional Authors: RATHNAYAKE JAYEWARDENE, SATHYAJITH AMBAWATTE, NAYOMISHERMILA JAYASINGHE, RAVI WIJESINGHE, PUBUDU DE SILVA, NARTHANI RASENDRAN Corresponding Author: RAVINDRA SATARASINGHE Affiliations: Sri Jayewardenepura General Hospital Objective: To study the demographics and other related matters in a cohort of adult Sri Lankans having oesophageal varices. Methods: Case notes of upper gastrointestinal endoscopies of consecutive patients admitted to the principle author’s unit at Sri Jayewardenepura General Hospital, Kotte, Sri Lanka from 15th of February 2002 to 15th February 2013 were retrospectively analyzed
to obtain the required information. Results: Out of 2728 endoscopy findings analyzed, 599 had oesophageal Oxymatrine varices (22%). Sex distribution Male: Female was 5: 1. Alcoholic: non alcoholic was 7: 3. Mean age of the population was 56.1 ± 12.5 SD years. Only one female patient found to have varices secondary to alcoholic liver disease. Banding had been done in 37.2%. Prophylactic banding alone was done in 4.2%. Indications for upper gastrointestinal endoscopy had been haematamesis, variceal surveillance, malena and isolated portal hypertension in 29.5%, 29.5%, 22.5% and 10.7% respectively with overlaps. Sclerotherapy alone was offered in 13.9%. Follow up was effected only in 11.7% with rebanding in 21.5% within 3 to 6 months. Conclusion: Sex discrimination was less marked in non-alcoholics. Upper gastrointestinal bleeding was the commonest presentation.