Concentrations, and that the compounds which originally are modulated as t Dliche or identified toxic to hair cells may, at the regeneration at lower concentrations. We identified two compounds that are obtained Hte regeneration. Glucocorticoid dexamethasone and prednisolone are two Synthetics, which many physiological processes confinement Lich regulate immune response. Both drugs is believed to primarily as anti-inflammatory, inhibition of macrophage activation and cytokine production. A CHANGE OF immune response may be their effect on the regeneration of hair cells based. W During Gewebesch To be recruited leukocytes to sites of injury and play an R Important in tissue repair. Rules at V, Increases the Wohnbev Lkerung of leukocytes into the inner ear sensory epithelia after trauma, before the proliferation of precursor Shore cell hair cells. The secretion of TGF and TNF by macrophages in the F Promotion of cell proliferation in the avi Ren utrikul Ren support after the damages caused associated. In contrast to our results, the use of glucocorticoids From shown that proliferative regeneration after Sch Ending hair cells in V Reducing gel. Zebrafish fin regeneration is strongly inhibited by the activation of GR and the GR target gene expression. Our data suggest that dexamethasone and prednisolone, the regeneration of hair cells in zebrafish f Rdern by mechanisms other than immunosuppression. We found that TCR Pathway glucocorticoids The F Promotion of Erh Increase the number of hair cells in the absence of exposure to neomycin demonstrate that they have more hair cells get independent Ngig of bulk products to. In addition, had other classes of anti-inflammatory drugs in the libraries not stero Including Dian Lich anti-inflammatory drugs, have no effect on the regeneration of hair cells. Dexamethasone and prednisolone may instead act directly on precursors of hair cells. Since we see only a modest increase in the number of hair cells, k They can on a subset of precursors that are ready to act to divide.
Alternatively, the glucocorticoid With the completion of the regeneration of st Ren. Although it m Is possible that glucocorticoid Can influence the immune cells to keep the number of hair cells in the normal course of regeneration, which was not observed in the imaging time of regeneration hair cells after exposure to neomycin. Nevertheless, our data do not directly address the issue of immunosuppression. Whether the effects of dexamethasone and prednisolone on the hair cells by GR activation is also unknown. Further studies are needed to explore fully the possibilities M. We believe it is surprising that so little regeneration enhancers were identified in our screen. To date, the secretase inhibitor DAPT, the only drug that relationships in the zebrafish in a position above the Owned erh Was the hair is cell regeneration. DAPT acts by interfering with the Notch signaling pathway thought to be a way to regulate the number of regenerated hair cells in fish, and V Gel important. The relative rarity of regeneration enhancer can k Reflect the composition of the library screening, interviews a gr Ere variety of small molecules, the new compounds able to f is the recovery Rdern reveal k Nnte. Inhibitors of regeneration of hair cells from primary Ren and secondary Ren experiments identified differ in structure and function. We further characterized.