So, this size range has not drawn considerable attention for use in EPZ004777 molecular weight hyperthermia treatment.   The key factor to obtain the maximum SAR in conventional

clinical hyperthermia treatments (f = 120 kHz, μ 0 H max =20 mT, T = 300 K) is the anisotropy of synthesized nanoparticles. Calculations of SAR as a function of anisotropy in several size regimes reveal that the maximal SAR would be obtained at the single-domain ferromagnetic size regime [17]. So, producing high-moment magnetic nanoparticles in this range is of high value from technical and clinical aspects. There are several GSK1838705A works dealing with the magnetic properties of iron compounds including its oxides and alloys for use in hyperthermia treatment [14–19]. For example, Hong et al. have synthesized Fe3O4 nanoparticles using selleck co-precipitation method and have shown that magnetic fluids of Fe3O4 nanoparticles which are coated with a surfactant bilayer feature high stability even after diluting and autoclaving and

therefore are suitable for being used in magnetic hyperthermia treatment [16]. Among iron compounds, FeCo alloys are known to exhibit the highest magnetic properties. Iron and cobalt are both near the peak of the Slater-Pauling curve and have maximum saturation magnetization when combined together. Fe0.7Co0.3 has the highest saturation magnetization among all magnetic alloys [20]. Till now, several methods have been used to synthesize G protein-coupled receptor kinase FeCo alloy nanoparticles which include arc discharge [21], polyol [2], hydrothermal process [6], RAPET [7], thermal decomposition

[9], wet chemical methods [10, 11], and co-precipitation [13]. The morphology and size distribution of as-synthesized nanoparticles are not well controlled in most of these processes. To attain the best properties for magnetic hyperthermia, the size distribution is an effective parameter. Researches show the loss of SAR due to the size distribution of nanoparticles. So, employing a method capable of producing monodisperse nanoparticles is very important. Also, stabilizing the magnetic fluid to prevent the agglomeration of nanoparticles is necessary so that the magnetic properties of the fluid would not change with time. Among all synthetic routes, the microemulsion technique has the capability of controlling the shape, size, and size distribution of nanoparticles [21]. In this process, the precipitation of nanoparticles takes place inside nanocages called micelles. The micelle is in the form of sphere or cylinder of oil in water (normal micelle) or water in oil (reverse micelle) which is surrounded by a layer of surfactant molecules [22]. The morphology of micelles depends on the type of the surfactant and water-to-surfactant molar ratio (R). The technique could be used to synthesize mineral [23] or organic compounds [24] inside the nanoreactors.