Results: EORA patients were associated with high HAQDI (>= 1) in bivariable analysis [odds ratio (OR) 1.36, confidence interval (CI) 1.04-1.77]. However, in multivariable analysis, not elderly onset but patients’ age, female gender, high disease activity, disease duration over 10 years, and comorbidity find protocol with cardiovascular disease were associated with high HAQDI. Only in a predefined subgroup with disease duration <10 years, elderly onset was an independent influencing factor
for the functional disability of RA patients (OR 3.04, CI 1.85-5.67: disease duration of <5 years, OR 3.07, CI 1.64-5.74: disease duration of 5 to 10 years).
Conclusions: Disease onset in older age was associated independently with functional disability of RA patients who have relatively short disease duration. (C) 2012 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 42:23-31″
“Background: Severe peritoneal injury and encapsulating peritoneal sclerosis (EPS) as complications of long-term peritoneal dialysis (PD) are issues of concern. The usefulness of peritoneal lavage after withdrawal of PD and the risk factors for EPS have not been addressed until now. Little is known about mesothelial cell area (MCA) in the effluent as a marker of peritoneal injury. In the present study, we investigated the clinical significance of peritoneal lavage after PD withdrawal and tried to clarify the risk factors
related to MCA, with the aim of preventing EPS. We also developed an algorithm for the clinical management of long-term PD patients.
Methods: Prexasertib molecular weight We assigned 247 PD patients to one of two cohorts after PD withdrawal: a non-lavage group (73 patients) and a lavage group (174 patients). To clarify the Evofosfamide Others inhibitor risk factors, we studied these potential predictors: PD duration, dialysate-to-plasma ratio of creatinine (D/P Cr)
at the time of PD withdrawal, frequency of peritoneal lavage, type of PD or lavage solution, MCA at the time of PD withdrawal (“”PD area”"), and MCA at the time of peritoneal lavage withdrawal or censoring (“”LA area”"). Recurrent intestinal obstruction was defined as the main manifestation of EPS. Diagnostic performance and cut-off values were then calculated for the selected risk factors.
Results: The overall incidence of EPS was significantly lower in the lavage group, at 6.9% (5.2% during lavage and 2.5% after lavage), than in the non-lavage group, at 15.1%. The risk factors and cut-off values were PD area (350 mu m(2)) and PD duration (78 months) for the non-lavage group; and PD area (350 mu m(2)) and LA area (320 mu m(2)) for the lavage group. Patients with a PD duration of 78 months or more and a PD area of 350 mu m(2) or more were defined as high-risk patients in the non-lavage group (risk ratio: 11.14), and patients with a PD area of 350 mu m(2) or more and an LA area of 320 mu m(2) or more were defined as high-risk patients in the lavage group (risk ratio: 10.43).