Post hoc group comparisons of mean CMI were performed using Scheffe’s post hoc test (SPSS version 12.0). A two-tailed P-value of less than 0.05 was considered significant. Results Clinical characteristics (age, sex, and MMSE scores) among different groups are shown in Table 1. The younger participants were significantly younger than the elderly

Inhibitors,research,lifescience,medical and MCI groups, but there was no statistical difference Diabete between elderly and MCI groups with respect to age. Mean MMSE scores were not significantly different between the younger and elderly groups. However, compared with the MCI groups, the younger and elderly groups had significantly better MMSE scores. Table 1 Clinical characteristics and examples of average values and standard deviations from the CMI data (electrodes: CP3–F4) among the younger, elderly, and MCI groups For the CMI analysis, the synchronization between the CP3–F4 electrodes (both long-range and interhemispheric connections) was used as an example to show representative results (Table 1). CMI data analyzed with ANOVA revealed Inhibitors,research,lifescience,medical significant main effects among the groups in the δ band

(F2, 44 = 13.01; P < 0.001), θ band (F2, 44 = 29.75; P < 0.001), β band (F2, 44 = 7.25; P < 0.01), α band (F2, 44 = 11.86; P < 0.001), and γ band (F2, Inhibitors,research,lifescience,medical 44 = 4.91; P < 0.05). There were significant differences in all frequencies between the younger and MCI groups. However, it is difficult to explore whether this change in frequencies is due to age-related or MCI disease-related Inhibitors,research,lifescience,medical features. Table 1 presents the post hoc comparisons between the younger and elderly groups, and the elderly and MCI patients groups to further clarify which frequency bands of task-related brain

oscillations could reflect the changes between age- and MCI disease-related changes using CMI analysis. Compared with the elderly group, the younger group revealed significantly higher CMI data in the δ, θ, α, and β bands, but did not reveal significant differences in the γ band. In contrast, only the θ band was Inhibitors,research,lifescience,medical significantly different between the elderly and MCI groups. In Figure 3, the CMI data are represented by red lines connecting the two paired electrodes that showed a significant inhibitor Pacritinib effect. In other words, Figure 3 shows the topographic Batimastat map describing the electrode pairs between which significant differences in CMI values (P < 0.05) were found. When an electrode pair revealed significant differences in CMI values, a red line will show between the two electrodes of this pair. Statistical analyses showed significant differences in the CMI of the δ band between the elderly and younger groups among the frontal, fronto-central, central, centroparietal, and parietal electrodes (e.g., F3–CP3, FC3–FCZ, FC3–CZ, CP3–CP4, CP3–P3, P3–FZ; Fig. 3A). However, significant differences in the δ band between the elderly and MCI groups were only observed between the parietal and occipital electrodes (e.g.