Physics had its Newton, biology its Darwin: evolutionary biology now awaits its Einstein.”
“The design and fabrication methods utilizing soft photocurable nanoimprint lithography to realize single longitudinal

mode distributed feedback transistor lasers are investigated. Coupled-mode theory and the effective index method are used to determine accurately the periodic dimensions necessary to integrate a surface grating in the top emitter AlGaAs confining layers of an InGaP/GaAs/InGaAs heterojunction bipolar transistor laser. Electrical and optical device data confirm the design methods. The distributed feedback device produces continuous wave https://www.selleckchem.com/products/VX-680(MK-0457).html laser operation with a peak wavelength lambda=959.75 nm and threshold buy BVD-523 current I(B)=13 mA operating at -70 degrees C. For devices with cleaved ends a side mode suppression ratio >25 dB has been achieved. (C) 2010 American Institute of Physics. [doi:10.1063/1.3504608]“
“For centuries, fiber has been recommended on an empirical basis for the management of constipation: it has only been in recent decades that the mechanisms whereby fiber and related products may influence colonic function have begun to be elucidated. The interaction between fiber and the microbiota of the human colon appears to play a major role in generating the beneficial effects of fiber. The microbiota is also the target for

the other therapeutic interventions discussed in this chapter: prebiotics and probiotics. While a scientific basis for a role for these approaches in the

management of constipation continues to develop, evidence from high-quality clinical trials to support their use in daily practice continues to lag far behind. While benefits for fiber and, perhaps, for certain prebiotic and probiotic preparations in constipation appear to be extant there is a real need for large well-conducted clinical trials in this important area of human medicine. (C) 2011 Elsevier Ltd. All rights reserved.”
“Human life expectancy in developed countries has increased steadily for over 150 years, through improvements in public health and lifestyle. More people BMS-345541 mouse are hence living long enough to suffer age-related loss of function and disease, and there is a need to improve the health of older people. Ageing is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. This view has been reinforced by the realization that ageing is a disadvantageous trait that evolves as a side effect of mutation accumulation or a benefit to the young, because of the decline in the force of natural selection at later ages. However, important recent discoveries are that mutations in single genes can extend lifespan of laboratory model organisms and that the mechanisms involved are conserved across large evolutionary distances, including to mammals.