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“Pain control is an issue which may limit patients’ acceptance of day case shoulder surgery.
This study prospectively examined the outcome of a protocol for day case shoulder surgery to determine U0126 in vivo if satisfactory pain relief could be achieved without regional anaesthesia.
Patients attended for pre-assessment and were informed about the procedure and day case protocol. Anaesthesia used was either a regional anaesthetic block or subacromial bursal block. Patients were discharged with a standard pain pack. All 117 operations were performed arthroscopically. Patients were contacted 24 h following surgery by an independent observer.
Based on 90 completed surveys, all patients were satisfied. Pain was well controlled in 85% of patients but 50% of the remaining patients did not take the prescribed pain pack. Problems other than pain were seen in only 4% of patients. No patients required overnight admission.
Our study indicates a very high level
GSK3326595 nmr of patient satisfaction and good pain relief without the use of regional anaesthesia for patients undergoing shoulder surgery as a day case.”
“Objective/background: Patients with peripheral arterial occlusive disease (PAOD), in particular critical limb ischaemia (CLI), carry a high risk of thrombotic events. We hypothesised that patients undergoing conservative, endovascular, or open surgical treatment for CLI have increased levels of plasminogen activator
inhibitor-1 (PAI-1), leading to a prothrombotic state. The objective was to determine levels of PAI-1 in patients with acute or chronic PAOD/CLI.
Methods: Thirty-two patients with a median age of 74 (49-90) selleck chemical years were included. Three underwent thrombolysis for acute limb-threatening ischaemia. Twenty-six patients with chronic ischaemia received endovascular (n = 20) or open (n = 6) surgical treatment. Three were treated conservatively. Biomarkers and ankle brachial index (ABI) were measured before and up to 1 month after intervention. Patency was studied with repeated duplex ultrasound.
Results: Ankle pressure and ABI improved after intervention (p < .001). C-reactive protein (CRP) increased from a median of 7.90 mg/L at baseline to 31.5 on day 1 (p < .001), 28.0 on day 6 (p < .001), and returned to baseline levels on day 30. PAI-1 antigen and activity decreased from day 6 and onwards post-intervention compared with baseline (p < .05). A great individual variability in PAI-1 antigen and activity was observed. Although most actively treated patients had normal PAI-1 activity, 11/29 (38%) were above that level of normality at baseline, 10/24 (42%) on day 1, 3/23 (13%) on day 6, and 5/27 (19%) on day 30 after intervention.
Conclusion: Endovascular and open surgical treatment resulted in improved ankle pressure and ABI.