Nature 2008, 455:822–825.PubMedCrossRef 51. Arita K, Ariyoshi M,
Tochio H, Nakamura Y, Androgen Receptor Antagonist cell line Shirakawa M: Recognition of hemimethylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature 2008, 455:818–821.PubMedCrossRef 52. Hashimoto H, Horton JR, Zhang X, Bostick M, Jacobsen SE, Cheng X: The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature 2008, 455:826–829.PubMedCrossRef 53. Hashimoto H, Horton JR, Zhang X, Cheng X: UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics 2009, 4:8–14.PubMedCrossRef 54. Achour M, Fuhrmann G, Alhosin M, Rondé P, Chataigneau T, Mousli M, click here Schini-Kerth VB, Bronner C: UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity. Biochem Biophys Res Commun 2009, 390:523–528.PubMedCrossRef CX-6258 cost 55. Qin W, Leonhardt H, Spada F: Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J Cell Biochem 2011, 112:439–444.PubMedCrossRef 56. Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, Kao HY, Xu Y, Willis J, Markowitz SD, Sedwick D, Ewing RM, Wang Z: DNMT1 stability is regulated by proteins coordinating deubiquitination and
acetylation-driven ubiquitination. Sci Signal 2010, 3:ra80.PubMedCrossRef 57. Bronner C: Control of DNMT1 Abundance in Epigenetic Inheritance by Acetylation, Ubiquitylation, and the Histone Code. Sci Signal 2011, 4:pe3.PubMedCrossRef 58.
Jin W, Chen L, Chen Y, Xu SG, Di GH, Yin WJ, Wu J, Shao ZM: UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer. Breast Cancer Res Treat 2010, 123:359–373.PubMedCrossRef 59. Egger G, Liang G, Aparicio A, Jones PA: Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004, 429:457–463.PubMedCrossRef 60. Pandey M, Shukla S, Gupta S: Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer http://www.selleck.co.jp/products/Decitabine.html cells. Int J Cancer 2010, 126:2520–2533.PubMed 61. Unoki M, Brunet J, Mousli M: Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis. Biochem Pharmacol 2009, 78:279–288.CrossRef 62. Mousli M, Hopfner R, Abbady AQ, Monté D, Jeanblanc M, Oudet P, Louis B, Bronner C: ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. Br J Cancer 2003, 89:120–7.PubMedCrossRef 63. Jeanblanc M, Mousli M, Hopfner R, Bathami K, Martinet N, Abbady AQ, Siffert JC, Mathieu E, Muller CD, Bronner C: The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle. Oncogene 2005, 24:7337–7345.PubMedCrossRef 64.