Moreover, there was no significant difference between the serum levels of TG, total cholesterol, LDL-C, or HDL-C of the diabetic control and the SBO-treated (200 or 600 mg/kg/day) groups (table 1). There was also no significant difference between

the effects of the two oils (PSO and SBO) on such variables. Table 1 Serum lipid profile Inhibitors,research,lifescience,medical and levels of the indices of CB-839 mw oxidative stress (mean±SD, n=8) of the control rats and diabetic rats treated with vehicle, pomegranate seed oil at 200 (PSO1) or 600 mg/kg/day (PSO2), or SBO at 200 mg/kg/day (SBO1) or 600 mg/kg/day … Serum concentrations of MDA (P=0.04) and GPX (P=0.001) of the diabetic control rats were, respectively, higher and lower than those of the normal control rats (table 1). Neither PSO nor SBO affected serum MDA significantly compared to that of the diabetic control group.  Neither Inhibitors,research,lifescience,medical PSO nor SBO (200 mg/kg/day) affected serum GPX significantly compared to that of the diabetic control group. However, the serum levels of the GPX of the group treated with PSO at 600 mg/kg/day was significantly higher than those of the diabetic control group and the diabetic group treated with SBO at 600 mg/kg/day (P=0.005) (table 1). Discussion The findings of the present study

Inhibitors,research,lifescience,medical indicate that a simultaneous administration of Nicotinamide and Streptozocin resulted in type 2 diabetes mellitus, characterized by increased blood glucose, lipid profile, and oxidative stress as well Inhibitors,research,lifescience,medical as with decreased serum insulin. They also showed that PSO increased serum

insulin and decreased oxidative stress, without affecting serum lipid profile. The present model of diabetes was associated with decreased serum insulin and increased blood glucose. Such findings are similar to those of previous studies using the same model of diabetes15 or other models of diabetes.16 The model was also associated with increased oxidative stress, which is similar Inhibitors,research,lifescience,medical to that of previous studies.4,5 The findings of the present study indicate that PSO did not decrease blood glucose. To the best of our knowledge, this is the first report to evaluate the effect of PSO in an animal model of type 2 diabetes, whereas previous investigations focused mainly on hyperlipidemic6,7,17or normal animals8 or hyperlipidemic subjects.11 The lack of PSO effect on blood glucose Methisazone is similar to that of previous reports.6,7 Such a finding might be due to the presence of insulin resistance, since fat administration is associated with insulin resistance. The study also showed that PSO increased the serum levels of insulin, but such an increase did not translate into the reduction of blood glucose level. Although the insulin secretion capacity of PSO has not been evaluated previously, improvement in insulin resistance was reported to be significant in hyperlipidemic animals.6,7 The mechanism of a PSO-induced increase in serum insulin is not clear.