\n\nMethods: Fifteen macaque monkeys received unilateral randomized doses of the selective dopaminergic neuronal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. We compared blinded validated ratings of parkinsonism to in vitro measures of striatal dopamine and unbiased

stereologic counts of nigral neurons after tyrosine hydroxylase immunostaining.\n\nResults: The percent of residual cell counts in lesioned nigra correlated linearly with the parkinsonism score at 2 months (r = -0.87, p<0.0001). The parkinsonism score at 2 months correlated linearly with the percent residual striatal dopamine (r = residual striatal dopamine (r = -0.77, p = 0.016) followed by a flooring effect once nigral cell loss exceeded, p = 0.016) followed by a flooring effect once nigral cell loss exceeded 50%. A reduction of about 14 to 23% of nigral neuron counts or 14% to 37% of striatal dopamine was sufficient to BGJ398 induce mild parkinsonism.\n\nConclusions: The nigral cell body and terminal field injury needed to produce parkinsonian motor manifestations may be much less than previously thought. (c) 2012 Elsevier Inc. All rights reserved.”
“In this study, antioxidant, antimicrobial and anticancer activities of the methanol extract of the lichen Stereocaulon paschale were GSI-IX supplier determined by: free radical and superoxide anion scavenging activity,

reducing power, determination of total phenolic compounds and determination of total flavonoid content, the minimal inhibitory concentration by the broth microdilution method against five species of bacteria and five species of Small molecule library mw fungi and the microculture tetrazolium test on FemX (human melanoma) and LS 174 (human colon carcinoma) cell lines. As a result of the study methanol extract of Stereocaulon paschale had moderate free radical scavenging activity with IC50 values 879.56 mu g/mL. Moreover, the tested extract had effective reducing power and superoxide anion radical scavenging. Values of minimum inhibitory concentration against the tested microorganisms ranged

from 0.625 to 10 mg/mL. In addition, the tested extract had a strong anticancer activity towards both cell lines with IC50 values of 46.67 and 71.71 mu g/mL.”
“In current clinical practice, increasing number of situations make necessary the use of molecular biology tests to help clinicians in charge of patients with colorectal cancer (CRC) in their therapeutic decisions: indication of adjuvant chemotherapy after colorectal surgery, treatment choice in case of unresectable metastatic CRC. Advances in pharmacogenetics allowed a better characterization of inherited causes of CRC and to identify prognostic and predictive factors for different treatments. The purpose of this article is to present the recent advances in the use of molecular biology in case of suspected Lynch syndrome and indication of anti-EGFR antibodies. To cite this journal: Oncologie 14 (2012).