Methods After a day of dietary control and caffeine PARP activity abstinence, otherwise-fasted participants performed four separate, strict squat jumps (SJ) under both conditions 48 – 96 hours apart. The variables measured included peak power (POW), peak force (FOR), peak velocity (VEL), maximal displacement (DSP), and maximal rate of force development (RFD) in the SJ for both Redline® energy drink and PLB trials. Results These preliminary data illustrated a significant increase in peak velocity in the Redline® energy drink condition versus PLB (Redline® 2.35± 0.36 m/s vs. PLB 2.29± 0.34 m/s [p= 0.033]). All

other variables were regarded as non-significant. Conclusion Our early findings only partially support our hypothesis STI571 because all but one variable was unaffected during the squat jump. Future research should focus on potential differences between upper- and lower-body power exercises as they respond to caffeine-related interventions.”
“Background Multi-ingredient performance supplements (MIPS) intended for consumption in close proximity to resistance exercise are extremely popular among young males [1, 2] and athletes [3]. The composition of MIPS vary widely, but the principle ingredients generally GSI-IX molecular weight include creatine monohydrate, caffeine, beta alanine, the branched chain amino acids (BCAAs) leucine, isoleucine, and valine, as well as L-citrulline,

and L-arginine. Most of these ingredients have been shown singularly [4–10] and in combination [11–14] to exert ergogenic effects during aerobic and anaerobic exercise or facilitate muscle hypertrophy over the course of a resistance training (RT) period in untrained participants. Claims about effectiveness and ergogenic enhancements provided by MIPS are often not supported by empirical data and

worse, frequently reflect poor understanding or even a misappropriation of the underlying science. Accordingly, it is of importance to consumers and researchers that MIPS be evaluated in double-blinded, placebo-controlled trials. While there is a considerable Urease body of research on the individual effects of creatine, caffeine, beta alanine and protein/amino acid consumption in proximity to exercise [4, 6, 9, 15–20], there is a paucity of data regarding the combined effect of these ingredients on exercise performance with RT [14, 21, 22]. The limited evidence available suggests that MIPS products of this general composition may offer an advantage for those wishing to increase muscle mass and strength. Smith et al. supplemented twenty-four moderately-trained recreational athletes with a pre-workout supplement (Game Time®, Corr-Jensen Laboratories Inc., Aurora, CO), containing 18 g of a proprietary blend including whey protein, cordyceps sinensis, creatine monohydrate, citrulline, ginseng, and caffeine [11, 12]. Participants in this study performed nine high intensity interval run training sessions over 3 weeks. Participants consumed Game Time® or placebo 30 minutes prior to each training session.