Inhibitory effect of mAb HER2 overexpression versa, the signal S pHER2 Ttigungszone and sensitivity of the RSS of its low starting point. Note that the results of Pimecrolimus Elidel sensitivity analysis of the t of our model of cell signaling in PE04 showed the r The role of HER3 receptor signaling through Akt in HRG, in which control over the size E is the excited strip FIG. 3A. This result is consistent with the results of the analysis of the model stimulated Akt signaling sensitivity in A431 cells by HRG and ADRR and thus reflects the R The key HER3 receptor in HRG-induced activation of act the effects of HER2 overexpression on the SRSS and pertuzumab sensitivity, i HER3 concentrations are low because the signal remains pHER2 S Saturation with respect to the concentration of HER3 in Idarubicin Topoisomerase inhibitor these cases Cases . Our results showed different reactions doses of pertuzumab in RSS and SN, and PACT respectively in Figure 2B.
In order to analyze their mutual relationship, we calculate the sensitivity of the RSS feeds, STS, and SN-wide for pertuzumab, the SSRS, SST, and SSN. SRSS and the NHS on the Candesartan 139481-59-7 basis of the dose- PHER2 dependence calculated for PACT and pertuzumab have been derived from the relationship SSSS SSTSSSN / SRSS. As illustrated, shows the sensitivity of t of the SN, SSN, overlaps with SRSS, but a gr Ere sensitivity to high concentrations of pertuzumab. This difference between the sensitivities of the SN and RSS is determined by the sensitivity of the STS, SST, and we analyze the properties of STS in detail. 3.2. Response and signal sensitivity of the transition resistance in the signal transmission system to study the sensitivity of the transition resistance in the signal transmission system, STS, we calculated the dependence Of the signal PACT pHER2 output of the input signal and control parameter dependence,. Figure E all, N1 according to the nature of oppression, a sensitive manner, and, 0.5 resistance mode 4A dependence Dependence of PACT is shown Fostamatinib for three characteristic values of e,. The Dependence Of PACT for a variety of pHER2 and If values in Fig S2 in the supplement. We used the PACT PACT profiling Dependence Ver signal changes in response to various requirements of the St STS: Specific inhibition of the input signal with pertuzumab, changing values and pHER2 PTEN, PI3K and AKT mutations, changing well.
For example, reduced pHER2 1 to 0.1 due to inhibition leads to a decrease in RTK signal S Saturation value of 1 to 0.2 to PACT, 1 The loss of PTEN activity T done by a reduction, From 1 to 0.5 leads to the restoration of the signal S Saturation resistance, and pertuzumab PACT. RTK inhibition and changes the mode of the STS-mode S Saturation of nonphotochemical how the transition from the anf Shown membrane nglichen state 1 to state 2. The operation of the STS not in S Saturation is different in S From saturation when not only by reducing the signal PACT but also by increasing Increase the sensitivity of the STS to the input signal, pHER2. To demonstrate this, we calculate the dependency Dependence of sensitivity on the SSSS and the concentration pHER2, 30 min after HRG stimulation. We pr Sentieren the same trajectory as in Figure 4A. A reduction of the signal pHER2 following causes inhibition of the RTK SSSS sensitivity to about 50 times erh Increase in the figure. 4B. The loss of PTEN.