Ah, the r The androgen and androgen-modulating agents IVF poor responders. The increased production of endogenous androgens intraovarian decreased conversion of androgens into Estrogens, androgens are exogenous administration, all operations on the target addicted Be intra ovarianandrogen concentrations. The underlying theory of GSK461364 intra-ovarian androgens f Rdern sensitivity to FSH growing follicles, and thus, the yield and maturity of the oocytes after stimulation of Eierst Hen eggs and CKE to improve pregnancy rates increased. For the verification of available data on all relevant interventions, w Re it easier for the reader to evaluate critically, to take the plausibility t this theory and the necessary conclusions.
In this context it should be noted that in all Ma Participated in this meta-analysis of the direction of the effect thereof are analyzed for the clinical pregnancy rate, although there was statistically significant only in the case of transdermal testosterone for the PXD101 addition of androgens or androgen modulating agent. This k An indication of the plausibility nnte t of the underlying theory. Interestingly though, on the basis of the theory for the follicles with increasing intra-ovarian androgens increased Ht proposed, one would expect that the increased interventions evaluated in the current meta-analysis w Re there, the number of COCs again Hen , reduce the total dose of gonadotropins required and reduce the duration of stimulation of Eierst skirts. Only in the transdermal administration of testosterone all of these hypotheses best CONFIRMS.
In view of aromatase inhibitors, the total dose of gonadotrophins was in fact considerably reduced, but the number of COC was not significantly different. The addition of hCG with a lower consumption of gonadotropins and a reduction in the duration of the stimulation associated. On the other hand, was not next to rLH compared with differences between the two groups in total FSH dose, duration of ovarian stimulation and COC won assigned. These inconsistent results highlight the M Possibility that the studied ma Took m Have looked like enough, not all have the same effect or not act through the same mechanism. In addition, k Can various parameters such as the nature of the substance, timing and duration of treatment are important factors for the effectiveness of these interventions.
Security is one of the most important parameters of any proposed treatment and to evaluate the safety of interventions in this meta-analysis deserves comment. Use of aromatase inhibitors to stimulate Eierst skirts with an increased Hten incidence of malformations associated literature although his schl Gt also reassuring. The effect of letrozole on perinatal health is not evaluated in this meta-analysis were asked the lack of relevant data from eligible studies. In Similar way, k Nnten administration of exogenous androgens also cause for concern for the health of the patient and the pregnancy that followed nnten k. The administration of testosterone through the skin, however, and the use of DHEA at a dose of 75 mg appear to be safe because no side effects and no abnormalities were identified in a studi of the matter