Gastritis. Both studies included FAK Inhibitors patients who developed a bleeding ulcer after the use of low-dose aspirin. In a study by Chan et al, 138 for the healing of ulcers and eradication of H. pylori, if present, 320 patients were randomized to receive either clopidogrel 75 mg / day or 80 mg of aspirin twice / day plus esomeprazole 20 mg for 12 months obtained. The cumulative incidence of recurrent bleeding was 8.6% for patients who again U CLO clopidogrel and 0.7% among those who received aspirin and esomeprazole. 138 In a study by Lai et al, 139 170 patients with previous ulcer bleeding were randomized to treatment with clopidogrel assigned to 75 mg / d aspirin or 100 mg / day and esomeprazole 20 mg / day for 1 year. The cumulative incidence of recurrent ulcer complications was 13.6% and 0% respectively. 139 The combination of esomeprazole and low-dose aspirin is superior to clopidogrel for Pr Prevention of recurrent gastrointestinal bleeding, as it now from the 2008 guidelines of the American College of Cardiology / American College of Gastroenterology recommended Heart / American Association. 140 much less information available about the risk of intracranial bleeding with aspirin use are connected. In the Nurses Study cohort of 79,000 healthy women aged 34 to 59 years was the rare use of aspirin with a reduced risk of isch Mix of stroke associated w was Taken during the use of radio frequency in conjunction with an increased Hten risk of subarachnoid hemorrhage , especially when older or hypertensive women. 141In the overview of the Antithrombotic Trialists 2002 10 together, was the entire surplus of the total intracranial bleeding due to aspirin therapy involved less than one in 1,000 patients per year in the studies that patients at high risk for kardiovaskul Re events, with a bit on the higher risk in patients with zerebrovaskul Ren diseases. The 2009 meta-analysis of individual patients in the primary Ren Pr Prevention studies suggests that aspirin with fi ve additionally USEFUL h Hemorrhagic Schlaganf Was associated cases per 1000 among participants with moderate risk over 5 years, but much less events in low-risk participants. 87 Treatment with low-dose aspirin has not been reported to affect renal function or controls The TA 142 are consistent with its lack of effect on renal prostaglandins expressed in the first line 143 fa Is constitutive COX -2 in the kidney. 84 Furthermore, aspirin 75 mg / d did not affect BP or the need for antihypertensive treatment in patients with hypertension treated intensively. 89 The suggestion that the use of aspirin and other platelet aggregation inhibitor in patients with left ventricular hereBenefit Rer systolic Funktionsst Enalapriltreated tion 144 is reduced, is associated with, endorsed by the results of a meta-analysis of studies with high MI. 145 Treated similar to any negative interaction between inhibition of the angiotensin-converting enzyme and the beneficial cardiovascular low-dose aspirin in patients with hypertension occurred intensively. 146 The ACE Inhibitors Collaborative Fesoterodine Group conducted a systematic review of the data from 22.060 patients in six long-term randomized trials of ACE inhibitors include assessing whether the effects of aspirin-inhibitor therapy VER Changed in important clinical outcomes ACE. 147 Although the results of this analysis made, the M Possibility of an interaction, they clearly show that, although aspirin.