And was not as active as a regime TMC PZA. Treatment with RIF PAPZA formonths onlyofmice healed. This result was lower than that with INH RIF PZA before, but after watching, the adjustment for multiple comparisons. However, all Mice Similar lung CFU relapse and, when recurrent BX-795 PDK-1 Inhibitors isolated fromrandomly selected Hlt M usen On their sensitivity to PA were evaluated were PAMICs h Compared her to the recurrent isolates with the relative isolation of HRV, suggesting that the selection of mutants PAresistant probably the sterilizing activity of t found this system hrdet. The effectiveness of treatment in the experiment. Lung CFU addressed at the time. On the day after aerosol infection, the mean lung CFU log number. In D, the average number of CFU obtained Ht. Untreated animals were moribund in the fourth week of infection.
The number of lung CFU are shown in Table S in the Fig.and additionally Are tzlichen material. Compared to D, treatment with INH RIF PZA formonth reduces the average number of CFU on Count. Connection is made. All test images were significantly better than INH RIF PZA, au He RPT PAMXF PAMXF and Celecoxib Celebrex TMC. Theregimens TMCPZA with more or RPT and MXF are most effective, reducing by at least UFC. Sign months after treatment. After these treatments was markedly PZA MXF RPT Higher than the other combinations au He TMC MXF RPT. However, TMC was not statistically significant RPTMXF h Ago PAPZA MXF, PZA, or PA RPT PAMXF. A note on the basis of CFU months after treatment were comparable. TMC PZA RPT renderedofmice negative culture, and the mouse still recognized justCFU.
Mice re U TMC-PZA and MXF-RPT PZAMXF betweenandCFU had recognized au It in the group thatofmice MXF RPT PZA culture was negative. Based on statistical comparisons with the figures of monthCFU classification schemes was as follows: RPT PZA PA TMC RPTMXFPAPZA MXFRPT PAMXFTMC PAMXF. The out action Of the last regime was, again, not those of INH RIF Rolipram PZA. Relapse after treatment. The results of a relapse are shown in the table. Relapse occurred in months with RIF INH PZA allmice treated, followed bymonthsof RIF INH. The recidivism rate among the h Controlled higher animals At this point in experimentcompared experimentwas on the result of the increase in bacterial load at the beginning and is consistent with previous experiments.
Month While treatment was not sufficient to prevent relapse in each group tested, months of therapy to prevent relapse in all mice M, The TMC TMC PZA PZA-MXF RPT andof recipients. MXF RPT PZA not heal Mice atmonths. These results indicate that to prevent in combination with other drugs PZA, TMC a gr Ere F Ability, relapse of RPT and MXF. The other groups were h Her lung CFU ofmonths the end of treatment and, not surprisingly, had positive cultures after months monitoring. Months after treatment, the pattern of savings or more TMC PZA MXF RPT or relapse PAprevented harmless Mice, a much better result than that obtained with the RIF INH PZA. Four months of treatment with MXF PAPZA was sufficient to return to M Mice prevent harmless, a result that was significantly better th