Used novel Raf MEK and PI3K act mTOR inhibitors: rgeting cancer-initiating cells Ta A glimpse of Raf and MEK, ERK PTEN PI3K Akt mTOR signaling pathways in some new aspects of its use is shown in Figure 4. Targeting these pathways k Nnte be an approach for overcoming resistance to chemotherapy drugs. An area of intense research in experimental therapeutics, AS-252424 the cancer stem cell, called specifically cancer cell initiation. CIC often share some properties with resistant cells to drugs, because both are often resistant to chemotherapy and hormonal therapies. The capacitance Inhibitors of Raf, MEK and mTOR, as well as various natural product resveratrol for targeted suppression of the proliferation of CIC are examined starting. It is not clear whether Raf or MEK inhibitors target the CIC.
CICs have unique properties of most cancers, in particular, because they. At rest and also resistant to chemotherapy CX-4945 and hormone-based drugs may be able k, Often obtained because of their FITTINGS expression of proteins involved in the transport of drugs, as well as the PI3K Akt mTOR PTEN But under certain conditions again they should proliferation and therefore potentially sensitive: Raf, MEK, PI3K, Akt, mTOR and Raf inhibitors that k against other MEK, Erk and PI3K pathways mTOR PTEN Nnte very important in terms of elimination of CIC. The microenvironment of the tumor probably plays an r Crucial role in the survival and metastasis of CIC also reemergence and following. Combinations of cytotoxic chemotherapy and inhibitors targeting the Raf MEK ERK, PI3K and mTOR kinase upstream Rts can PTEN may be an m Glicher approach to target tumor microenviroment but Zielspezifit t be a significant problem.
The F ability, The tumor microenvironment is a difficult question target. MiRNAs have recently shown that many genes involved in resistance and regulations that may regulate CIC. miRNA specific 3 UTR of the gene PTEN was shown to be up-regulated in certain cells of ovarian cancer, and can be entered dinner cisplatin resistance. We k Can speculate that it m Possibly the miRNA expression Hnlichen or erg Nzenden CIC ver Change their sensitivity to mTOR inhibitors and other comparable Be changed. The p53 pathway and the stability properties Genome instability T play an r Key in the regulation of many aspects of cell growth, including CIC.
We know very little about the Ver Changes in p53 stability t and instability to the genome that occur in the first CIC CIC k Can smarter, which can be present k In sp More advanced stages of tumor progression. When we. More about the effects of p53 and the response to DNA-Sch On the CIC and learn how they develop, k We may be able to targeted these biochemical events and inhibit tumor progression Your Raf MEK ERK rgeting the PTEN and PI3K Akt mTOR pathway suppress cellular Re senescence Quiesence Raf MEK ERK and PI3K Akt mTOR PTEN pathways play an r Crucial role in the regulation of cellular Ren senescence and tranquility. Escape from drug-induced senescence has also been associated with resistance and CIC in conjunction. Often, a key molecule involved in extra:’s Responses to DNA Sch p53, cell aging and drug resistance, whose activity is regulated by the Raf t