Altogether, these findings underscore the potential therapeutic application of NO donors and subtoxic chemotherapeutic drugs in the treatment of advanced colon cancer resistant to conventional chemotherapeutic agents. Published by Elsevier Inc.”
“We have described a new compound (trans-[RuCl([15]ane N(4))NO](2+)), which in vitro releases NO by the action of a reducing agent such as catecholamines. We investigated the effect

of this NO donor in lowering the mean arterial pressure (MAP) in severe and moderate renal hypertensive 2K-1C rats. MAP was measured before and after intravenous in bolus injection of the compound in conscious 2K-1C and normotensive (2K) rats. In the hypertensive rats (basal 196.70 +/- 8.70 mmHg, n=5), the MAP was reduced CHIR-99021 ic50 in -34.25

+/- 13.50 mmHg(P < 0.05) 6 h after administration Cl-amidine in vitro of 10 mmol/L/Kg of the compound in bolus. In normotensive rats the compound had no effect. We have also studied the effect of the injection of 0.1 mmol/L/Kg in normotensive (basal 118.20 +/- 11.25 mmHg, n = 4), moderate (basal 160.90 +/- 2.30 mmHg, n = 6), and severe hypertensive rats (basal 202.46 +/- 16.74 mmHg, n = 6). The compound at the dose of 0.1 mmol/L/Kg did not have effect (P> 0.05) on MAP of normotensive and moderate hypertensive rats. However, in the severe hypertensive rats (basal 202.46 +/- 16.70 mmHg, n = 6) there was a significant reduction on the MAP of -28.64 +/- 12.45 mmHg. The NO donor reduced the MAP of all hypertensive rats in the dose of 10 mmol/L/Kg and in the severe hypertensive www.selleck.cn/products/mk-4827-niraparib-tosylate.html rats at the dose of 0.1 mmol/L/Kg. The compound was not cytotoxic to the rat aortic vascular smooth muscle cells in the concentration of 0.1 mmol/LKg that produced the maximum relaxation. (C) 2008 Elsevier Inc. All rights reserved.”
“Nitric oxide metabolites (NOx) in serum, and alveolar

concentration of NO (CA(NO)), are markers of inflammation and alveolitis, respectively, in systemic sclerosis (SSc). We prospectively evaluated the usefulness of both NOx and CANO to assess lung involvement and skin fibrosis in SSc. Serum NOx, and CANO measured by two different methods, namely the two-compartment (2CM) and the “”trumpet”" models (TM), were concomitantly assessed in 65 patients with SSc and 17 healthy controls. Whilst serum NOx remained comparable between groups, CANO were significantly higher in SSc patients (n = 65, 6.7 ppb; 4.8-9.7 and 5.9 ppb; 3.9-8.9) as compared with controls (n = 17, 3.0 ppb; 2.0-3.8 and 1.8 ppb; 1.1-2.9, p < 0.001, p < 0.001) using the 2CM and the TM, respectively). CANO from SSc patients with interstitial lung disease (ILD) (n = 26, 8.6 ppb; 6.5-10.9 and 8.5 ppb; 5.9-10.7) or pulmonary arterial hypertension (n = 12, 7.3 ppb; 6.5-10.4 and 6.9 ppb; 5.4-9.