e assessed using unpaired two-tailed A66 1166227-08-2 t tests. Data involving more than two groups were assessed by analysis of variance. Statistical significance is displayed as P 0.05 or P 0.01 in figures. ACKNOWLEDGMENTS. We thank R. Hoshino, F. Takahashi, Y. Kanto, and Y. Kishida for their excellent technical assistance. This work was supported by a grant for the Translational Systems Biology and Medicine Initiative from the Ministry of Education, Culture, Sports, Science and Technology of Japan , a Grant-in-Aid for Scientific Research in Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan , a Grant-in-Aid for Scientific Research in Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan , a Grant-in-Aid for Scientific Research from the Ministry of Health, Labor and Welfare , Health Science Research grants from the Ministry of Health and Welfare , and a grant from Takeda Science Foundation.
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