We also present a brief review of the literature on this subject.”
“The TLC-Ag dressings, a combination of technology lipido-colloid and silver salts, are used to promote healing in wounds with risks or signs of local infection, thanks to the antimicrobial properties of the silver salts. Nanocrystalline silver dressings containing nanocrystalline silver, also used to improve wound healing, present both antimicrobial and anti-inflammatory effects. The aim of this Selleck Bafilomycin A1 study was to investigate the anti-inflammatory effects of TLC-Ag dressings in a model of chronic skin
inflammation induced by repeated application of 12-O-tetradecanoylphorbol-13-acetate to the skin of hairless mice, in comparison with TLC dressing, Silcryst nanocrystalline dressing, desonide cream 0.05%, a corticoid cream used as positive control, and gauze. Daily treatments of the mice began 7days after the start of induction of chronic skin inflammation and lasted for 7days. A macroscopic score was performed daily during the treatment period until the mice killing on day 15 and skin samples were taken for histopathological analysis. TLC-Ag reduced significantly the macroscopic score of chronic skin inflammation from day 10 in comparison with gauze and TLC dressing, similarly to Silcryst nanocrystalline dressing and VX-680 desonide cream, which presented
the best anti-inflammatory effects. No significant differences were observed
between TLC dressing and gauze. TLC-Ag reduced significantly the microscopic score of chronic skin inflammation in comparison with TLC dressing and gauze, similarly to Silcryst nanocrystalline dressing but significantly less than desonide cream. These results demonstrate that TLC-Ag dressings present significant anti-inflammatory effects on chronic skin inflammation. They can improve wound healing, due to both the antimicrobial and anti-inflammatory properties.”
“Background: It is well known that patients with uremia, as well as patients with diabetes mellitus, develop polyneuropathy.
Objectives: The signs of polyneuropathy in diabetic and nondiabetic patients on continuous ambulatory peritoneal dialysis (CAPD) and their relation with age, LCL161 supplier duration of dialysis, biochemical parameters, dialysis adequacy, and health-related quality of life (HRQOL) were analyzed in the present study. “” Patients and Methods: 65 CAPD patients (37 men, age 29 – 85 years, duration on dialysis 3 months to 14 years) were divided into two groups: group 1 was comprised of 20 diabetic patients (mean age 50.1 +/- 13.2 years); group 2 was comprised of 45 nondiabetic patients (mean age 62.3 +/- 9.7 years). Biochemical parameters, dialysis adequacy, and clinical signs were determined.