The review of the literature revealed 4 reports with a total of 9 patients who received TCZ for PMR. In 7 of these 9 patients, PMR was associated with giant cell arteritis. Including our patients, 5 patients received TCZ alone and 6 TCZ plus GC. A good response to TCZ treatment was observed in all patients reported in the literature without any major adverse events.
Conclusions: TCZ both as monotherapy and in association with GC appears to be mostly effective and safe to treat patients with PMR. However,
larger controlled studies are required to confirm these favorable data. (C) 2013 Elsevier Inc. All rights reserved.”
“Background: Endometrial Stromal Sarcoma(ESS) is a rare uterine malignancy which often metastasizes several years after initial diagnosis. Thoracic spine is a rare ESS metastatic site ACY-1215 inhibitor and its proper management is still not a consensus. We discuss the histopathological features and the management strategies through an illustrative case of a 77 year-old woman with metastasis to the thoracic spine 13 years after total hysterectomy for ESS.
Methods: Review of
the literature and identification of 5 patients, including our present case, with ESS involving the spinal cord. We discuss the outcomes achieved after each therapy. In our case, the 4EGI-1 patient presented a mass involving the thoracic spinal canal constricting the spinal cord at T7 level. A two-level decompression laminectomy was performed and the lesion was partially excised.
Results: The histopathological along with the immunohistochemical profile mitotic rate indicated the endometrial stromal cells origin of the tumor, confirming the diagnosis of a low-grade ESS metastasis. The patient was managed with surgery in combination with postoperative radiation therapy.
Conclusions: selleckchem The small number of published cases precludes definitive conclusions regarding standard
management. However, it seems that treatment of metastatic ESS to the spine matches the same general concepts of spine metastasis, namely surgery followed by radiation therapy, due to clinical improvement and long-term disease control of the reported cases. Hormonal therapy may be considered in recurrent disease with strong expression of estrogen and progesterone receptors. However, these findings need confirmation in larger studies. (C) 2010 Elsevier Ltd. All rights reserved.”
“Magnetic hysteresis loss and refrigerant capacity of the NaZn13-type La0.5Pr0.5Fe11.5-xCoxSi1.5 (0 <= x <= 1.0) compounds have been investigated. The substitution of Co in the La0.5Pr0.5Fe11.5Si1.5 causes the order of phase transition at T-C to change from first order to second order at x=0.6. Although the magnetic entropy change decreases with increasing Co concentration, the hysteresis loss at T-C also reduces remarkably from 94.8 J/kg for x=0 to 1.8 J/kg for x=0.4 because an increase in Co content can weaken the itinerant electron metamagnetic transition.