124). When technical failures were evaluated based on the route of access, compared with phase I, there were significantly less failures in phase II for both transduodenal (24.4% vs 3.5%; P < .001)

and transgastric (7.6% vs 0.5%; P < .001) procedures. There was no difference in the overall rates of diagnostic adequacy between phases I and selleck screening library II at 97.1% versus 98.4% (P = .191), respectively ( Table 3). Also, there was no difference in rates of procedural complications between phase I and II procedures (0.4% vs 0.2%; P = 1.0), respectively. Two patients in phase I after FNA of pancreatic masses encountered procedural complications that included mild pancreatitis in one and abdominal pain in the other. The patient with pancreatitis required hospitalization for 2 days, and the patient with abdominal pain was managed conservatively. One patient in phase CX-5461 purchase II developed bleeding after FNA of a common bile duct mass that was managed conservatively with the patient as an outpatient. The average cost of one FNA needle per patient was

significantly less in phase II compared with phase I at $188.30 versus $199.59 (P = .008). In this study, we validated a simple algorithm for better technical outcomes and resource use at EUS. These findings are important, given the increasing number of EUS-FNA procedures and/or interventions being performed and decreasing reimbursements from insurance carriers for endoscopic procedures. Although not well-studied, technical failure due to needle dysfunction is not an uncommon occurrence during EUS procedures. Although there are no studies PtdIns(3,4)P2 that have specifically compared the relationship between technical outcomes and needle caliber as the main outcome measure, in a prospective

trial that evaluated the 19-gauge Tru-Cut biopsy, 22-gauge, and 25-gauge needles for EUS-FNA of pancreatic mass lesions, the technical success rates of the 19-, 22-, and 25–gauge needles were 0%, 33.3%, and 100% for lesions in the uncinate process, 33.3%, 83.3%, and 100% for lesions in the pancreatic head, and 83.3%, 100%, and 100% for pancreatic body and/or tail lesions, respectively.3 The superiority of the 25-gauge needle assembly for transduodenal FNA stems from its thin caliber because it enables easy exit from the biopsy channel even when the tip of the echoendoscope is acutely angulated. Based on published literature3 and our observations, in phase II of this study, we used the 25-gauge needle exclusively for transduodenal FNAs and the 22-gauge needle for other FNAs. In 3 randomized trials that compared the performance of the 22- and 25–gauge needles, there was no statistical difference in technical performance or diagnostic yield between the two needle types.12, 13 and 14 However, in two of the studies, there was a trend toward better performance of the 25-gauge needle, particularly for pancreatic head and/or uncinate lesions.