N1 amplitude in humans marks the transition zone between perceptual processes partly driven by stimulus characteristics and partly affected by cognitive operations. It is often associated with cognitive functions such as stimulus encoding and the formation of a trace in the sensory memory (Näätänen and Picton 1987; Posner and Driver 1992). Explicitly focusing on specific characteristics of the paradigm, namely, speech stimuli, may lead to an increased neural responsiveness Inhibitors,research,lifescience,medical and therefore to stronger activation

when processing the attended stimulus. The present observation of stronger N1 amplitudes in OA versus YA in the two tasks could be interpreted as a compensatory mechanism in the aging brain. By virtue of the recruitment of additional neurons, OA maintain their potential synchronous neural firing. The absence of an age × attention interaction indicates an attention-independent, general enhancement of potential involved neuronal

ensembles. Thus, this mechanism may not be specifically attributed to stimulus encoding or processing of auditory speech and nonspeech Inhibitors,research,lifescience,medical material, but may also apply in other modalities. The recruitment of a wider activation pattern as a probable compensatory Inhibitors,research,lifescience,medical mechanism in OA has been documented to occur in other cognitive domains (Cabeza 2002). However, Rao and colleagues associated the N1 component with task difficulty and task-related cognitive Inhibitors,research,lifescience,medical effort (Rao et al. 2010). Our findings fit with their interpretation, by revealing stronger N1 activity in speech stimuli as compared to nonspeech stimuli. Possibly, the differentiation between

words and pseudowords requires more cognitive effort compared to distinguishing between noise stimuli of different durations because any presented speech stimuli must be matched with the participants’ mental lexicon before a decision about its lexical status can be made. In contrast, it is obviously Inhibitors,research,lifescience,medical easier to decide about the duration of an acoustic stimulus, represented by only two possible options. One may now wonder whether enhanced N1 amplitude in OA compared to YA can be interpreted as reflection of additional cognitive effort in OA. However, we assume it is more likely that a group-related difference in allocation of cognitive effort would occur at a later stage of stimulus processing tuclazepam and would thus be probably reflected by modulations of a late positivity. P2 peak In this study, we measured enhanced P2 peak amplitude in YA compared to OA. Furthermore, whereas YA showed a task-related modulation of this component, no such modulation pattern could be observed in OA. The P2 component in OA GSK1349572 chemical structure rather seems to be uninfluenced by the focus of attention or by any characteristics of the presented stimuli. P2 amplitude is usually associated with inhibitory processes and protection against interference from irrelevant stimuli (García-Larrea et al. 1992; Senderecka et al. 2012).