medreviews.com]). Age as an independent risk factor for UI was analyzed in 8 studies,37,42,67,91,120,122,126,128 with significant positive association with #Baricitinib randurls[1|1|,|CHEM1|]# total UI in 2 studies42, 67 and urge UI (OR 5.34; 95% CI, 2.26–12.62) among those older than 70 years compared with younger men in 1 study.37 Diabetes demonstrated consistent positive association with UI (selleck chem inhibitor Figure 2). Comorbidities and poor

general health were associated with UI in several studies (Table 1).38,42,90,93 The presence of fecal incontinence was associated with an increased odds of urge UI in 1 study of 2198 men (OR 17; 95% CI, 7.5–40)117 but with random changes in another.58 Men with arthritis had higher adjusted odds of total UI (OR Inhibitors,research,lifescience,medical 1.6; 95% CI, 1.1–2.4)54 and urge UI (OR 1.8; 95% CI, 1.4–2.4).117 The National Population Health Survey in Canada reported that use of narcotics, laxatives, and diuretics Inhibitors,research,lifescience,medical was associated with greater odds of UI independent of other risk factors.54 Memory problems, epilepsy, and neurologic diseases were associated with higher rates of UI.35,42,54,67,101,117,125 Stroke was associated with UI (Figure 2) in community-dwelling men (pooled OR 2.7; 95% CI, 1.3–5.5) with variable estimations from individual studies, depending on time of follow-up and definitions of UI. Restrictions Inhibitors,research,lifescience,medical in activities of daily living were associated with higher adjusted odds of UI in men in all studies that examined the relationship.42,49,58,93 Figure 2 Association between

risk factors and prevalence of urinary incontinence (adjusted odds ratios from individual studies and pooled analysis with random-effects models). CI, confidence interval. Men with Inhibitors,research,lifescience,medical urinary tract infections had higher adjusted odds of UI (Figure 2), with a pooled OR of 3.6 (95% CI, 2.17–6).35,37,42,58,93 Men with prostate diseases had higher rates of UI after adjustment for Inhibitors,research,lifescience,medical confounding factors in the majority

of studies.71,93,117,126 Prostate cancer (RR 2; 95% CI, 1.5–2.8), radical prostatectomy (RR 4.3; 95% CI, 2.6–7.3), and radiotherapy for prostate cancer (RR 2.3; 95% CI, 1.3–4.1) were associated with increased adjusted relative risk of UI.71 Clinical Interventions for UI in Community-Dwelling Men Outcome: Continence. Behavioral interventions Entinostat for UI in men with prostate diseases were examined in 10 RCTs (Table 3; Appendix Table 2 [available at www.medreviews.com]).129–137 Continence rates in the control groups were more than 60% across all RCTs, with no statistically significant differences compared with active treatments. The highest continence rate was reported in a large well-designed RCT of early pelvic floor rehabilitation in patients who had radical retropubic prostatectomy for clinical stage T1 or T2 prostate cancer136 (Figure 3). The majority of patients (99%) reported continence after the intervention that included verbal explanations, palpation, and Kegel exercises, with a small significant relative benefit compared with usual care (RR 1.1; 95% CI, 1.1–1.2).