Due to their high prevalence, some have considered their coexistence as an incidental event, while others have

argued that acute appendicitis may cause the citation patient to be vulnerable to a traumatic event.4 In our case, visceral hypoperfusion and resultant increased IAP does not seem to have a pathophysiological role due to the absence of a significant volume loss. Appendiceal rupture after blunt abdominal trauma is also exceedingly rare. Whether appendiceal rupture occurs as a complication of advanced acute appendicitis or as a consequence of direct blunt abdominal trauma has yet to be fully clarified. In our case, concurrence of appendiceal rupture and acute appendicitis rendered it difficult to determine Inhibitors,research,lifescience,medical which one was prior to the other. As we mentioned, the

patient had been asymptomatic before the trauma and there was no histopathological evidence Inhibitors,research,lifescience,medical of advance acute appendicitis to be responsible for the subsequent appendiceal rupture. Furthermore, consideration of transaction as an antecedent event does not justify the pathologic report of inflammation because of trauma-induced vascular injury and tissue ischemia. Appendiceal rupture was first Inhibitors,research,lifescience,medical reported in 1938 with a two-week history of pneumatic drill use resting on the right iliac fossa.8 In 1977, a 30-year-old man was reported to have developed acute abdominal pain two days after a blunt severe direct trauma to the abdomen. Surgical exploration revealed appendix avulsion from its distal three quarters with fibrinopurulent mucosa and surrounding bruising of the cecal wall. Consequently, appendectomy and caecostomy were performed. Nonetheless, the patient experienced a complicated postoperative Inhibitors,research,lifescience,medical course due to the formation

of multiple subcutaneous parastomal abscesses and resultant septicemia.2 Reviewing the literature lists a few other such conditions.9-11 However, we found only one case of Inhibitors,research,lifescience,medical bicycle handlebar injury presented by acute appendicitis. In the said case, the bicycle handlebar had injured the lower abdomen and symptoms started 2 days after the trauma with the diagnosis of perforated suppurative appendicitis in pathological examination.12 The appendiceal transection in our case is in fact a contrecoup injury due to the opposite primary side of the handlebar harmful contact, which was visible in the left part of the patient’s abdomen. It is also worthy of note that in the majority of the available reports, late presentation of symptoms features prominently. Furthermore, in a patient Batimastat with trauma, diagnosis of acute appendicitis is difficult and may cause delay in early management.13 It may contribute to more complex pathologic forms of acute appendicitis. In our case, rapid development of the symptoms and signs of generalized peritonitis hinted at enzalutamide mechanism of action chemical peritonitis, which was subsequently confirmed by our observations during exploratory laparotomy. Our early management precluded such further problems as fibrinopurulent peritonitis and its complications.