In control group, there have been 19 men and 5 females aged from 20 to 60 yrs old with the average of (47.32±10.67) years old;7 patients were typeⅡ, 11 patients were type Ⅲ and 6 patients were type Ⅳ relating to Sanders classificoes perhaps not impact the exposure, decrease and fixation of break during procedure.Intermittent flap opening strategy is more advanced than static opening technique in decreasing incision complications of lateral “L” strategy of calcaneus. Single check details Kirschner wire orifice doesn’t affect the exposure, reduction and fixation of fracture during operation. To research medical effectation of percutaneous reduction coupled with inner fixation of calcaneal nail in treating Sanders typeⅡto Ⅲ calcaneal fractures. From July 2017 to August 2019, clinical data of 98 patients with Sanders typeⅡto Ⅲ calcaneal fractures treated had been retrospectively examined, and divided into observation group and control team relating to different surgical methods. In observation group, there have been 35 guys and 21 females, elderly from 23 to 58 yrs old with a typical of (34.50±7.81) yrs old;29 patients with Sanders typeⅡand 27 patients with Sanders type Ⅲ;30 patients in the remaining side and 26 clients from the right side;the time from fracture to operation ranged from 1 to 4 times with an average of (3.45±0.54) times;and treated with percutaneous reduction along with inner fixation of calcaneal nail system. In charge group, there have been 25 males and 17 females, aged from 25 to 60 years of age with a typical of (35.27±7.64) years of age;23 customers with Sanders type Ⅱ and 19 clients we, it may shorten procedure Biomedical science time, medical center stay, fracture recovery time, decrease number of loss of blood, promote postoperative recovery, and less complications, high security, which could be utilized as a choice of orthopedic surgery for foot and foot stress.Compared with available reduction and interior fixation, percutaneous decrease combined with inner fixation system in treating Sanders typeⅡto Ⅲ calcaneal cracks is simple for break fix without waiting for foot deswelling, that could precisely restore normal form and position of this fractured heel-bone, completely eliminate fracture malunion, and reduce postoperative problems. Consequently, it could reduce procedure time, medical center stay, fracture healing time, reduce number of loss of blood, promote postoperative recovery, much less problems, high security, which could be applied as a range of orthopedic surgery for base and ankle upheaval. Forty-one clients with complex Schatzker type Ⅳ tibial plateau fractures had been treated from January 2016 to January 2021, including 28 guys and 13 females, aged from 19 to 65 yrs old with a typical of (35.3±19.8) yrs old. Individualized treatment plan was developed relating to preoperative imaging traits, medial surgical approach was primarily coupled with various other auxiliary incisions. Posteromedial inverted L method ended up being used in 18 patients, posteromedial method and anterolateral extended approach in 19 customers, and posteromedial strategy with anterolateral and lateral condylar osteotomy in 4 clients. Articular area and facture healing were observed, range of knee-joint motion was assessed at one year after opertaion, and purpose of knee-joint was assessed by Lysholm scoring system. Forty-one customers had been followed up for 12 to 26 months with the average of (13.3±6.8) months. Twenty-nine patients and 10 tive fixation of posteromedial bone tissue blocks ought to be pay complete attention, while the overall therapy results are happy. To compare clinical efficacy of No-touch technique and old-fashioned retractor in treating calcaneal fracture. Clinical data of 74 calcaneal fracture patients with closed Sanders typeⅡ to Ⅳ were retrospectively analyzed from July 2019 to Summer 2021. In accordance with various treatments, the clients were divided into No-touch team and mainstream group, 37 patinets in each group. In No-touch group, there have been 25 men and 12 females, elderly from 19 to 70 yrs old with an average of (42.64±14.16) yrs old;17 patients were typeⅡ, 14 patinets with type Ⅲ, 6 patients with type Ⅳ according to Sanders fracture classification;three 2.0 mm Kirschner wires were implanted to the talus human body, talus throat, and cuboid bone, plus the flap had been turned upward to reveal the procedure area. In standard team, there were 30 guys and 7 females, elderly from 19 to 67 yrs . old with an average of (41.56±11.38) yrs old;17 patients with typeⅡ, 12 patients with type Ⅲ, 8 clients with type Ⅳ according to Sanders fracture clacores in No-touch group was considerably greater than compared to mainstream team ( Compared to old-fashioned retractor in dealing with calcaneal fracture, No-touch technology could considerably shorten operation time, reduce occurrence of postopertive problems, while two techniques could improve exemplary and great rate of rearfoot purpose recovery after operation.Compared to conventional retractor in managing calcaneal fracture, No-touch technology could significantly reduce operation time, lower incidence of postopertive complications, while two methods could enhance exceptional and great Long medicines rate of rearfoot purpose recovery after procedure. Seventy-two-hour TTA concentration response and inhibitor studies in immortalized cellular outlines. School of Pharmacy biomedical study laboratory and structure culture facility.