YR Ntgendosis produces results in about 105 events ionization, 1000 2000 BSN and 40 CBD. The majority of DSB repair occur within 2 h, but this repair process may take up to 24 hours after irradiation. Most of the Bezirksschulr-run of man is by non-homologous end-joining is fehleranf Llig and therefore repaired accounts for the outstanding mutagenic L Emissions, the induced by radiation. CSD also in the formation of chromosomal aberrations and other big fl Support chige rearrangements are also fa We have observed recurring in irradiated cells. L Sions of the base, with the exception of a few, led to the formation of thymine glycol and 8 play hydroxydeoxyguanosine, an R A minor in radiation-induced carcinogenesis. Radiation is also known point mutations and L To induce research. In most studies, has been found that radiation is responsible for the loss of heterozygosity, which is in turn involved in a number of cancers. 3.1.2. Beautiful to the lipids of biological membranes Haupts Chlich formed from lipids also negatively affected by IR irradiation. Generated free radicals are responsible for m Possible damages caused to the membranes. Oxidative Sch Ending of the membrane is usually by the removal of phospholipids, which gives the main components of the plasma membrane. This method is Haupts Chlich by the activation of the enzyme by IR sphingomyelinase, which converts sphingomyelin to ceramide in the Sunitinib Sutent membrane caused. Lipid peroxidation is a special event in the IR-induced Sch Ending of the cell. Peroxyl radical formation as a key step in lipid peroxidation. The peroxyl erf Leads endoperoxidases form a cyclization reaction, which in turn the precursors for the production of malondialdehyde.
MDA is known that with DNA bases A, C and G react to form DNA adducts. The OH radicals were generated as responsible for the implementation of lipid peroxidation. Other than the MDA is another aldehyde product of lipid peroxidation 4-hydroxy-2 nonenal. Both products are designed to be toxic and mutagenic Ndernd ugetieren systems in bacteria and South. Lipid peroxidation results in structural and functional adversely caning of cellular Ren machinery that crosslinking between molecules of the lipid changes and other commitments How Erh Increase in the dielectric tskonstante In the membrane by the accumulation of polar products. This affects the Mikroviskosit t and thus the scattering property of the membrane. IR exposure is also responsible for Change in the ion transport through the membrane. 3.1.3. Damages caused to proteins IR Sch Which the protein component of the cellular Ren machinery, either by direct action on the Warmth Ties of proteins, which cross-linking or by conversion of amino Acids or indirectly by redox reactions induced by ROS. The h Ufigsten chemical compounds Changes in proteins induced by IR include oxidation, carbonylation, and networking division. An early report of Sch Mediated ROS proteins Was given by Garrison by L solutions Of amino Acids and peptides in the IR. Early studies showed that the hydrogen atom is bonded to the alpha carbon skeleton of the protein polypeptide, and cha Ties of aliphatic side chains of amino Urereste are anf Lliger of oxidative Sch To. The oxidation of amino Acids lead to the production of glutamine Acid semialdehyde, 2 Aminoadipins Acid semialdehyde.